Beschreibung:
<jats:sec><jats:title>Background:</jats:title><jats:p> <jats:italic>H. pylori</jats:italic> eradication usually involves treatment with three or four drugs for at least 7 days. Possible advantages of short treatment regimens are better patient compliance and tolerability, and less adverse effects. Recently two reports have shown a cure rate of > 90% using a 4‐day quadruple therapy.</jats:p></jats:sec><jats:sec><jats:title>Aim:</jats:title><jats:p>To confirm these data and to evaluate the efficacy and tolerability of 4‐day quadruple therapy in a single centre.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>Thirty‐eight consecutive patients with non‐ulcer dyspepsia or peptic ulcer disease, and proven <jats:italic>H. pylori</jats:italic> infection, received 4 days of quadruple therapy (bismuth, tetracycline, metronidazole, lansoprazole). At least 6 weeks after treatment, endoscopy was repeated with six biopsies of antrum and corpus for histology and culture.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>The intention‐to‐treat cure rate was 34/38 (89.5%, 95% CI: 79.7–99.2%). In the per protocol analysis the cure rate was 34/37 (91.9%, 95% CI: 83.1–100%). Primary metronidazole resistance was observed in two patients; both were cured. Metronidazole resistance induction was observed in one patient in whom therapy failed. The treatment was generally well tolerated.</jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p>Routine use of 4‐day quadruple anti‐<jats:italic>H. pylori</jats:italic> treatment is effective and well tolerated.</jats:p></jats:sec>