• Medientyp: E-Artikel
  • Titel: Metabolic Status Modulates Choroidal Thickness – A Possible Early Indicator for Diabetic Eye Complications?
  • Beteiligte: Meyhöfer, Svenja; Wilms, Britta; Chamorro, Rodrigo; Knaak, Armin; Pappa, Eleni; Schulz, Agnetha S.; Pagels, Anna-Josephin; Schröder, Maria; Kaluzny, Neele; Grein, Hans-Jürgen; Meyhöfer, Sebastian M.
  • Erschienen: Georg Thieme Verlag KG, 2022
  • Erschienen in: Experimental and Clinical Endocrinology & Diabetes, 130 (2022) 12, Seite 789-792
  • Sprache: Englisch
  • DOI: 10.1055/a-1831-0265
  • ISSN: 0947-7349; 1439-3646
  • Schlagwörter: Endocrinology ; General Medicine ; Endocrinology, Diabetes and Metabolism ; Internal Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Abstract Objective To investigate the impact of metabolic status on choroidal thickness (ChT) in healthy subjects, patients with obesity, and type 2 diabetes. Design and Methods Fasting blood glucose, insulin, insulin-like growth factor-1 (IGF-1), and ChT measured by optical coherence tomography were assessed in healthy normal-weight (n=17), obese participants (n=20), and obese participants with T2D (n=16). Results ChT increased in obese participants and obese participants with T2D as compared to healthy normal-weight participants (P<0.0001). A negative correlation was observed between IGF1 and ChT (r=−0.268, P=0.050) for all cohorts. Furthermore, body mass index (BMI; R2=0.209; P=0.002; beta=0.388) and model assessment-estimated insulin resistance (HOMA-IR; R2=0.074; P=0.015; beta=0.305) were independent variables of ChT, explaining 20.9 and 7.4% of its variance (both p<0.016), whereas age, sex, and IGF-1 were not significant confounders of ChT (p>0.975). Conclusion ChT is associated with metabolic characteristics, i. e., BMI and HOMA-IR. Due to the key role of choroidal function in retinal physiology, future studies are needed to evaluate whether metabolic traits, ChT, and potential metabolic eye complications are mechanistically linked.