Beschreibung:
<jats:title>Abstract</jats:title><jats:p>The aim of this study was to investigate the impact of Supervised and Home-based
resistance exercise on the Kynurenine pathway in patients with pancreatic cancer
who underwent surgery and chemotherapy. In the SUPPORT study, adult pancreatic
cancer patients were randomized to intervention programs of 6-month (1) a
Supervised moderate-to-high-intensity progressive resistance training or (2)
unsupervised Home-based resistance training, or (3) to a standard care patient
Control group. Serum levels of kynurenine, tryptophan and IL-6 were assessed for
32 participants before, after 3 months and after 6 months of exercise
intervention. Group differences were investigated using analysis-of-covariance.
Patients in the Supervised training group showed decreased levels of serum
kynurenine and kynurenine/tryptophan ratio (p = 0.07; p
= 0.01 respectively) as well as increased Tryptophan levels (p =
0.05) in comparison to Home-based and Control group over time. The Home-based
exercise group had significant increased kynurenine and
kynurenine/tryptophan ratio levels. IL-6 levels decreased over the first
three months for both intervention groups as well as the Control group
(Supervised: p < 0.01, Home-based: p < 0.010, Control group: p
< 0.01). Supervised resistance exercise might positively regulate the
Kynurenine pathway and downregulate the kynurenine/tryptophan
(indicative of IDO/TDO enzyme) levels, hence modulating the immune
system.</jats:p>