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Storz, Corinna; Rospleszcz, Susanne; Askani, Esther; Rothenbacher, Theresa; Linseisen, Jakob; Messmann, Helmut; De Cecco, Carlo N.; Machann, Jürgen; Kiefer, Lena Sophie; Elser, Stefanie; Rathmann, Wolfgang; Peters, Annette; Schlett, Christopher L.; Bamberg, Fabian

Magnetic Resonance Imaging of Diverticular Disease and its Association with Adipose Tissue Compartments and Constitutional Risk Factors in Subjects from a Western General Population

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  • Medientyp: E-Artikel
  • Titel: Magnetic Resonance Imaging of Diverticular Disease and its Association with Adipose Tissue Compartments and Constitutional Risk Factors in Subjects from a Western General Population
  • Beteiligte: Storz, Corinna; Rospleszcz, Susanne; Askani, Esther; Rothenbacher, Theresa; Linseisen, Jakob; Messmann, Helmut; De Cecco, Carlo N.; Machann, Jürgen; Kiefer, Lena Sophie; Elser, Stefanie; Rathmann, Wolfgang; Peters, Annette; Schlett, Christopher L.; Bamberg, Fabian
  • Erschienen: Georg Thieme Verlag KG, 2021
  • Erschienen in: RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren
  • Sprache: Deutsch
  • DOI: 10.1055/a-1212-5669
  • ISSN: 1438-9010; 1438-9029
  • Schlagwörter: Radiology, Nuclear Medicine and imaging
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p> Purpose To determine the association of asymptomatic diverticular disease as assessed by magnetic resonance imaging (MRI) with adipose tissue compartments, hepatic steatosis and constitutional risk factors within a cohort drawn from a Western general population.</jats:p><jats:p> Materials and Methods Asymptomatic subjects enrolled in a prospective case-control study underwent a 3 Tesla MRI scan, including an isotropic VIBE-Dixon sequence of the entire trunk. The presence and extent of diverticular disease were categorized according to the number of diverticula in each colonic segment in a blinded fashion. The amount of visceral, subcutaneous, and total adipose tissue (VAT, SAT, and TAT) was quantified by MRI. Additionally, the degree of hepatic steatosis, indicated as hepatic proton density fat fraction (hepatic PDFF) was determined using a multi-echo T1w sequence. Constitutional cardiometabolic risk factors were obtained and univariate and multivariate associations were calculated.</jats:p><jats:p> Results A total of 371 subjects were included in the analysis (58.2 % male, 56.2 ± 9.2 years). Based on MRI, 154 participants (41.5 %) had diverticular disease with 62 cases (17 %) being advanced diverticular disease. Subjects with advanced diverticular disease had a significantly higher body mass index (BMI) (BMI: 29.9 ± 5.1 vs. 27.5 ± 4.6, p &lt; 0.001; respectively). Furthermore, all adipose tissue compartments were increased in subjects with advanced diverticular disease (e. g. VAT: 6.0 ± 2.8 vs. 4.2 ± 2.6 and SAT: 9.2 ± 3.6 vs. 7.8 ± 3.6, all p &lt; 0.001, respectively). Similarly, subjects with advanced diverticular disease had significantly higher hepatic PDFF (4.9 [2.7, 11.4] vs. 6.1 [5.5, 14.6], p = 0.002).</jats:p><jats:p> Conclusion Advanced diverticular disease is associated with an increased volume of adipose tissue compartments and BMI, which may suggest a metabolic role in disease development.</jats:p><jats:p> Key Points:</jats:p><jats:p> Citation Format </jats:p>