• Medientyp: E-Artikel
  • Titel: Cu(I)-Catalyzed Synthesis of β,γ-Unsaturated Amides
  • Beteiligte: Isaacs, André; Bosse, Aaron; Tsougranis, Gregory; DeTroia, Christopher; Tejidor, Francisco
  • Erschienen: Georg Thieme Verlag KG, 2018
  • Erschienen in: Synlett
  • Sprache: Englisch
  • DOI: 10.1055/s-0036-1589135
  • ISSN: 0936-5214; 1437-2096
  • Schlagwörter: Organic Chemistry
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>Readily available propargyl alcohols were found to be useful substrates for the copper(I)-catalyzed synthesis of β,γ-unsaturated amides. Nucleophilic attack by the alcohol on the in situ generated keten­imine followed by base-catalyzed elimination and subsequent ring opening yields the desired products under mild conditions.</jats:p>