Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Unraveling the Complexity of Liver Disease One Cell at a Time
Beteiligte:
Bader, Gary D.;
McGilvray, Ian D.;
MacParland, Sonya A.;
Atif, Jawairia;
Thoeni, Cornelia
Erschienen:
Georg Thieme Verlag KG, 2022
Erschienen in:
Seminars in Liver Disease, 42 (2022) 3, Seite 250-270
Sprache:
Englisch
DOI:
10.1055/s-0042-1755272
ISSN:
0272-8087;
1098-8971
Entstehung:
Anmerkungen:
Beschreibung:
The human liver is a complex organ made up of multiple specialized cell types that carry out key physiological functions. An incomplete understanding of liver biology limits our ability to develop therapeutics to prevent chronic liver diseases, liver cancers, and death as a result of organ failure. Recently, single-cell modalities have expanded our understanding of the cellular phenotypic heterogeneity and intercellular cross-talk in liver health and disease. This review summarizes these findings and looks forward to highlighting new avenues for the application of single-cell genomics to unravel unknown pathogenic pathways and disease mechanisms for the development of new therapeutics targeting liver pathology. As these technologies mature, their integration into clinical data analysis will aid in patient stratification and in developing treatment plans for patients suffering from liver disease.