Erschienen:
Proceedings of the National Academy of Sciences, 2005
Erschienen in:
Proceedings of the National Academy of Sciences, 102 (2005) 45, Seite 16374-16378
Sprache:
Englisch
DOI:
10.1073/pnas.0501724102
ISSN:
0027-8424;
1091-6490
Entstehung:
Anmerkungen:
Beschreibung:
Cellular telomere length is linked to replicative life span. Telomere repeats are lost in peripheral blood cellsin vivoby age, and women show less telomere attrition than men. Previous reports have indicated that telomere length and chromosome-specific telomere-length patterns partly are inherited. The mode of heredity has not been clarified, but a link to the X chromosome was recently suggested. We analyzed peripheral mononuclear cells from 49 unrelated families for telomere length using a real-time PCR method. Short-term cultured Epstein–Barr virus-transformed lymphoblasts from the same individuals (n= 130) were analyzed for ability to maintain telomere length and possible gender-linked inheritance. A statistically significant association between telomere lengths comparing father–son (P= 0.011,n= 20) and father–daughter (P= 0.005,n= 22) pairs was found. However, no correlation was observed between mother–daughter (P= 0.463,n= 23) or mother–son (P= 0.577,n= 18). The father–offspring correlation was highly significant (P< 0.0001), in contrast to mother–offspring (P= 0.361). Epstein–Barr virus cultures demonstrated in most cases telomere preservation inversely related to initial mononuclear cell telomere length with short telomeres displaying the most pronounced elongation. Telomere length is inherited, and evidence for a father-to-offspring heritage of this trait was obtained, whereasin vitrotelomere length maintenance was found to be dependent on the initial telomere length.