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Medientyp:
E-Artikel
Titel:
MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus
Beteiligte:
Bhoj, Vijay G.;
Sun, Qinmiao;
Bhoj, Elizabeth J.;
Somers, Cynthia;
Chen, Xiang;
Torres, Juan-Pablo;
Mejias, Asuncion;
Gomez, Ana M.;
Jafri, Hasan;
Ramilo, Octavio;
Chen, Zhijian J.
Erschienen:
Proceedings of the National Academy of Sciences, 2008
Erschienen in:
Proceedings of the National Academy of Sciences, 105 (2008) 37, Seite 14046-14051
Sprache:
Englisch
DOI:
10.1073/pnas.0804717105
ISSN:
0027-8424;
1091-6490
Entstehung:
Anmerkungen:
Beschreibung:
Infection by RNA viruses is detected by the host through Toll-like receptors or RIG-I-like receptors. Toll-like receptors and RIG-I-like receptors signal through the adaptors MyD88 and MAVS, respectively, to induce type I IFNs (IFN-I) and other antiviral molecules, which are thought to be essential for activating the adaptive immune system. We investigated the role of these adaptors in innate and adaptive immune responses against respiratory syncytial virus (RSV), a common human pathogen. Deletion ofMavsabolished the induction of IFN-I and other proinflammatory cytokines by RSV. Genome-wide expression profiling in the lung showed that the vast majority of RSV-induced genes depended on MAVS. AlthoughMyd88deficiency did not affect most RSV-induced genes, mice lacking both adaptors harbored a higher and more prolonged viral load and exhibited more severe pulmonary disease than those lacking either adaptor alone. Surprisingly,Myd88−/−Mavs−/−mice were able to activate a subset of pulmonary dendritic cells that traffic to the draining lymph node in response to RSV. These mice subsequently mounted a normal cytotoxic T-lymphocyte response and demonstrated delayed but effective viral clearance. These results provide an example of a normal and effective adaptive immune response in the absence of innate immunity mediated by MAVS and MyD88.