Baechler, Emily C.;
Batliwalla, Franak M.;
Karypis, George;
Gaffney, Patrick M.;
Ortmann, Ward A.;
Espe, Karl J.;
Shark, Katherine B.;
Grande, William J.;
Hughes, Karis M.;
Kapur, Vivek;
Gregersen, Peter K.;
Behrens, Timothy W.
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
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Medientyp:
E-Artikel
Titel:
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Beteiligte:
Baechler, Emily C.;
Batliwalla, Franak M.;
Karypis, George;
Gaffney, Patrick M.;
Ortmann, Ward A.;
Espe, Karl J.;
Shark, Katherine B.;
Grande, William J.;
Hughes, Karis M.;
Kapur, Vivek;
Gregersen, Peter K.;
Behrens, Timothy W.
Erschienen:
Proceedings of the National Academy of Sciences, 2003
Erschienen in:
Proceedings of the National Academy of Sciences, 100 (2003) 5, Seite 2610-2615
Sprache:
Englisch
DOI:
10.1073/pnas.0337679100
ISSN:
1091-6490;
0027-8424
Entstehung:
Anmerkungen:
Beschreibung:
Systemic lupus erythematosus (SLE) is a complex, inflammatory autoimmune disease that affects multiple organ systems. We used global gene expression profiling of peripheral blood mononuclear cells to identify distinct patterns of gene expression that distinguish most SLE patients from healthy controls. Strikingly, about half of the patients studied showed dysregulated expression of genes in the IFN pathway. Furthermore, this IFN gene expression “signature” served as a marker for more severe disease involving the kidneys, hematopoetic cells, and/or the central nervous system. These results provide insights into the genetic pathways underlying SLE, and identify a subgroup of patients who may benefit from therapies targeting the IFN pathway.