Obesity accelerates epigenetic aging of human liver

Medientyp: E-Artikel
Titel: Obesity accelerates epigenetic aging of human liver
Beteiligte: Horvath, Steve; Erhart, Wiebke; Brosch, Mario; Ammerpohl, Ole; von Schönfels, Witigo; Ahrens, Markus; Heits, Nils; Bell, Jordana T.; Tsai, Pei-Chien; Spector, Tim D.; Deloukas, Panos; Siebert, Reiner; Sipos, Bence; Becker, Thomas; Röcken, Christoph; Schafmayer, Clemens; Hampe, Jochen
Erschienen: Proceedings of the National Academy of Sciences, 2014
Erschienen in: Proceedings of the National Academy of Sciences
Sprache: Englisch
DOI: 10.1073/pnas.1412759111
ISSN: 0027-8424; 1091-6490
Schlagwörter: Multidisciplinary
Entstehung:
Anmerkungen:
Beschreibung: <jats:title>Significance</jats:title> <jats:p>Because obese people are at an increased risk of many age-related diseases, it is a plausible hypothesis that obesity increases the biological age of some tissues and cell types. However, it has been difficult to detect such an accelerated aging effect because it is unclear how to measure tissue age. Here we use a recently developed biomarker of aging (known as “epigenetic clock”) to study the relationship between epigenetic age and obesity in several human tissues. We report an unexpectedly strong correlation between high body mass index and the epigenetic age of liver tissue. This finding may explain why obese people suffer from the early onset of many age-related pathologies, including liver cancer.</jats:p>
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