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Chen, Zhuo;
Miao, Feng;
Paterson, Andrew D.;
Lachin, John M.;
Zhang, Lingxiao;
Schones, Dustin E.;
Wu, Xiwei;
Wang, Jinhui;
Tompkins, Joshua D.;
Genuth, Saul;
Braffett, Barbara H.;
Riggs, Arthur D.;
Natarajan, Rama;
Nathan, D. M.;
Zinman, B.;
Crofford, O.;
Genuth, S.;
Brown-Friday, J.;
Crandall, J.;
Engel, H.;
Engel, S.;
Martinez, H.;
Phillips, M.;
Reid, M.;
[...]
Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort
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- Medientyp: E-Artikel
- Titel: Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort
- Beteiligte: Chen, Zhuo; Miao, Feng; Paterson, Andrew D.; Lachin, John M.; Zhang, Lingxiao; Schones, Dustin E.; Wu, Xiwei; Wang, Jinhui; Tompkins, Joshua D.; Genuth, Saul; Braffett, Barbara H.; Riggs, Arthur D.; Natarajan, Rama; Nathan, D. M.; Zinman, B.; Crofford, O.; Genuth, S.; Brown-Friday, J.; Crandall, J.; Engel, H.; Engel, S.; Martinez, H.; Phillips, M.; Reid, M.; [...]
- Erschienen: Proceedings of the National Academy of Sciences, 2016
- Erschienen in: Proceedings of the National Academy of Sciences
- Sprache: Englisch
- DOI: 10.1073/pnas.1603712113
- ISSN: 0027-8424; 1091-6490
- Schlagwörter: Multidisciplinary
- Entstehung:
- Anmerkungen:
- Beschreibung: <jats:title>Significance</jats:title> <jats:p>Vascular complications are the main cause of morbidity and mortality in the diabetic population. Clinical trials of diabetic complications show a persistence of benefit from early application of intensive therapy for glycemic control in diabetic patients, a phenomenon referred to as metabolic memory. The mechanisms underlying metabolic memory are not fully understood. In this study, using two groups of type 1 diabetic patients with and without complications development and two sets of genomic DNAs collected 16–17 y apart from the same patients, we showed a persistency of DNA methylation over time at key genomic loci associated with diabetic complications. These data provide direct evidence of a relationship between epigenetics (DNA methylation variations) and human metabolic memory, supporting an epigenetic mechanism.</jats:p>
- Zugangsstatus: Freier Zugang