Role of the receptor Mas in macrophage-mediated inflammation in vivo

Medientyp: E-Artikel
Titel: Role of the receptor Mas in macrophage-mediated inflammation in vivo
Beteiligte: Hammer, Anna; Yang, Guang; Friedrich, Juliane; Kovacs, Agnes; Lee, De-Hyung; Grave, Katharina; Jörg, Stefanie; Alenina, Natalia; Grosch, Janina; Winkler, Jürgen; Gold, Ralf; Bader, Michael; Manzel, Arndt; Rump, Lars C.; Müller, Dominik N.; Linker, Ralf A.; Stegbauer, Johannes
Erschienen: Proceedings of the National Academy of Sciences, 2016
Erschienen in: Proceedings of the National Academy of Sciences
Sprache: Englisch
DOI: 10.1073/pnas.1612668113
ISSN: 1091-6490; 0027-8424
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Beschreibung: <jats:title>Significance</jats:title> <jats:p>The alternative renin–angiotensin system pathway, the angiotensin (Ang)-(1–7)/Mas axis, may counterbalance Ang II-mediated proinflammatory effects. To investigate the role of the Ang-(1–7)/Mas axis in immune cell function and inflammatory diseases in vivo, we used two different chronic inflammatory animal models. Deletion of Mas affects macrophage function and phenotype independently of the underlying phagocyte stimulus and aggravates the clinical course of experimental autoimmune encephalomyelitis as well as atherosclerosis in mice by tipping the in vivo balance from M(IL-4+IL-13)- to M(LPS+IFNγ)-like macrophages. Thus, modulation of the Ang-(1–7)/Mas axis counteracts the proinflammatory role of Ang II by regulating the delicate equilibrium between M(LPS+IFNγ)- and M(IL-4+IL-13)-like macrophages, thereby representing a promising pharmacological target for chronic inflammatory diseases.</jats:p>
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