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Dobroff, Andrey S.; D’Angelo, Sara; Eckhardt, Bedrich L.; Ferrara, Fortunato; Staquicini, Daniela I.; Cardó-Vila, Marina; Staquicini, Fernanda I.; Nunes, Diana N.; Kim, Kisu; Driessen, Wouter H. P.; Hajitou, Amin; Lomo, Lesley C.; Barry, Marc; Krishnamurthy, Savitri; Sahin, Aysegul; Woodward, Wendy A.; Prossnitz, Eric R.; Anderson, Robin L.; Dias-Neto, Emmanuel; Brown-Glaberman, Ursa A.; Royce, Melanie E.; Ueno, Naoto T.; Cristofanilli, Massimo; Hortobagyi, Gabriel N.; [...]

Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes

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  • Medientyp: E-Artikel
  • Titel: Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes
  • Beteiligte: Dobroff, Andrey S.; D’Angelo, Sara; Eckhardt, Bedrich L.; Ferrara, Fortunato; Staquicini, Daniela I.; Cardó-Vila, Marina; Staquicini, Fernanda I.; Nunes, Diana N.; Kim, Kisu; Driessen, Wouter H. P.; Hajitou, Amin; Lomo, Lesley C.; Barry, Marc; Krishnamurthy, Savitri; Sahin, Aysegul; Woodward, Wendy A.; Prossnitz, Eric R.; Anderson, Robin L.; Dias-Neto, Emmanuel; Brown-Glaberman, Ursa A.; Royce, Melanie E.; Ueno, Naoto T.; Cristofanilli, Massimo; Hortobagyi, Gabriel N.; [...]
  • Erschienen: Proceedings of the National Academy of Sciences, 2016
  • Erschienen in: Proceedings of the National Academy of Sciences
  • Sprache: Englisch
  • DOI: 10.1073/pnas.1615288113
  • ISSN: 0027-8424; 1091-6490
  • Schlagwörter: Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Significance</jats:title> <jats:p> Inflammatory breast cancer (IBC) is defined clinically and pathologically. Dermal lymphatic invasion is typical but is neither necessary nor sufficient for diagnosis; sentinel lymph node biopsy is contraindicated, challenging multidisciplinary management with upfront chemotherapy, surgery, and postoperative radiotherapy. Here we applied a ligand-directed “theranostic” (a combination of therapeutic and diagnostic) enabling platform to target IBC based on adeno-associated virus/phage (AAVP)- <jats:italic>Herpes simplex</jats:italic> virus thymidine kinase type-1 ( <jats:italic>HSVtk</jats:italic> ) particles displaying ligands to cell surface-associated 78-kD glucose-regulated protein (GRP78). In a suite of preclinical models and human tumor samples, we show simultaneous noninvasive molecular serial PET/CT imaging and targeted suicide transgene therapy. This study shows that a tumor-specific promoter, human <jats:italic>GRP78</jats:italic> ( <jats:italic>hGRP78</jats:italic> ), can drive the expression of an imaging/suicide transgene in IBC and aggressive breast cancer in vivo. </jats:p>
  • Zugangsstatus: Freier Zugang