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Medientyp:
E-Artikel
Titel:
Pre/pro-B cells generate macrophage populations during homeostasis and inflammation
Beteiligte:
Audzevich, Tatsiana;
Bashford-Rogers, Rachael;
Mabbott, Neil A.;
Frampton, Dan;
Freeman, Tom C.;
Potocnik, Alexandre;
Kellam, Paul;
Gilroy, Derek W.
Erschienen:
Proceedings of the National Academy of Sciences, 2017
Erschienen in:Proceedings of the National Academy of Sciences
Sprache:
Englisch
DOI:
10.1073/pnas.1616417114
ISSN:
0027-8424;
1091-6490
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Significance</jats:title><jats:p>In this report we provide evidence of a source of macrophage (Mφ) populations that are derived from unique biphenotypic early pro-B cells with non-rearranged B-cell receptors. These early precursors give rise to either tissue resident- or monocyte-derived Mφs during homeostasis and inflammatory responses, thereby demonstrating functional plasticity depending on the environmental cues in adult mice. We suggest that these findings significantly advance and expand our understanding of Mφ biology and hematopoiesis, the plasticity of hematopoietic precursors, and the heterogeneity of Mφ subsets.</jats:p>