Immune protection against reinfection with nonprimate hepacivirus

Medientyp: E-Artikel
Titel: Immune protection against reinfection with nonprimate hepacivirus
Beteiligte: Pfaender, Stephanie; Walter, Stephanie; Grabski, Elena; Todt, Daniel; Bruening, Janina; Romero-Brey, Inés; Gather, Theresa; Brown, Richard J. P.; Hahn, Kerstin; Puff, Christina; Pfankuche, Vanessa M.; Hansmann, Florian; Postel, Alexander; Becher, Paul; Thiel, Volker; Kalinke, Ulrich; Wagner, Bettina; Bartenschlager, Ralf; Baumgärtner, Wolfgang; Feige, Karsten; Pietschmann, Thomas; Cavalleri, Jessika M. V.; Steinmann, Eike
Erschienen: Proceedings of the National Academy of Sciences, 2017
Erschienen in: Proceedings of the National Academy of Sciences
Sprache: Englisch
DOI: 10.1073/pnas.1619380114
ISSN: 0027-8424; 1091-6490
Schlagwörter: Multidisciplinary
Entstehung:
Anmerkungen:
Beschreibung: <jats:title>Significance</jats:title> <jats:p>Hepatitis C virus (HCV) displays a narrow species tropism severely hampering development of small animal models that are required for vaccine and pathogenesis studies in vivo. The recent discoveries of HCV-related hepaciviruses in diverse hosts offer new opportunities with respect to the development of an immunocompetent animal model for HCV research. Among the hepaciviruses, the equine nonprimate hepacivirus (NPHV) represents the closest homolog of HCV discovered to date. We defined key aspects of natural immunity to NPHV challenge in the cognate host and provide evidence for natural protection from NPHV infection. Further characterization of the immune signatures that confer protection against NPHV could provide important information that may facilitate the development of new prophylactic strategies including protective vaccines against HCV.</jats:p>
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