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Iyer, Shilpa S.; Bibollet-Ruche, Frederic; Sherrill-Mix, Scott; Learn, Gerald H.; Plenderleith, Lindsey; Smith, Andrew G.; Barbian, Hannah J.; Russell, Ronnie M.; Gondim, Marcos V. P.; Bahari, Catherine Y.; Shaw, Christiana M.; Li, Yingying; Decker, Timothy; Haynes, Barton F.; Shaw, George M.; Sharp, Paul M.; Borrow, Persephone; Hahn, Beatrice H.

Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness

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  • Medientyp: E-Artikel
  • Titel: Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness
  • Beteiligte: Iyer, Shilpa S.; Bibollet-Ruche, Frederic; Sherrill-Mix, Scott; Learn, Gerald H.; Plenderleith, Lindsey; Smith, Andrew G.; Barbian, Hannah J.; Russell, Ronnie M.; Gondim, Marcos V. P.; Bahari, Catherine Y.; Shaw, Christiana M.; Li, Yingying; Decker, Timothy; Haynes, Barton F.; Shaw, George M.; Sharp, Paul M.; Borrow, Persephone; Hahn, Beatrice H.
  • Erschienen: Proceedings of the National Academy of Sciences, 2017
  • Erschienen in: Proceedings of the National Academy of Sciences
  • Sprache: Englisch
  • DOI: 10.1073/pnas.1620144114
  • ISSN: 0027-8424; 1091-6490
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Significance</jats:title> <jats:p>Effective prevention strategies are urgently needed to control the spread of HIV-1. A critical barrier to developing such strategies is the lack of understanding of the host antiviral defenses that control HIV-1 replication in the mucosa at the site of entry. Here, we characterized viruses from matched donor and recipient pairs to determine whether transmitted HIV-1 strains exhibit traits that increase their transmission fitness. Characterizing 300 limiting dilution-derived isolates, we identified several properties that enhance virus replication in the face of a vigorous innate immune response, of which resistance to type 1 IFNs is the most important. These results provide new insights into the HIV-1 transmission process and define possible new targets for AIDS prevention and therapy.</jats:p>
  • Zugangsstatus: Freier Zugang