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Medientyp:
E-Artikel
Titel:
An interacting network of T-box genes directs gene expression and fate in the zebrafish mesoderm
Beteiligte:
Goering, Lisa M.;
Hoshijima, Kazuyuki;
Hug, Barbara;
Bisgrove, Brent;
Kispert, Andreas;
Grunwald, David Jonah
Erschienen:
Proceedings of the National Academy of Sciences, 2003
Erschienen in:Proceedings of the National Academy of Sciences
Sprache:
Englisch
DOI:
10.1073/pnas.1633548100
ISSN:
0027-8424;
1091-6490
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>
T-box genes encode transcription factors that play critical roles in
generating the vertebrate body plan. In many developmental fields, multiple
T-box genes are expressed in overlapping domains, establishing broad regions
in which different combinations of T-box genes are coexpressed. Here we
demonstrate that three T-box genes expressed in the zebrafish mesoderm,
<jats:italic>no
tail, spadetail</jats:italic>
, and
<jats:italic>tbx6</jats:italic>
, operate as a network of interacting
genes to regulate region-specific gene expression and developmental fate.
Loss-of-function and gain-of-function genetic analyses reveal three kinds of
interactions among the T-box genes: combinatorial interactions that generate
new regulatory functions, additive contributions to common developmental
pathways, and competitive antagonism governing downstream gene expression. We
propose that T-box genes, like Hox genes, often function within gene networks
comprised of related family members.
</jats:p>