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Medientyp:
E-Artikel
Titel:
Host-derived fatty acids activate type VII secretion inStaphylococcus aureus
Beteiligte:
Lopez, Michael S.;
Tan, Irene S.;
Yan, Donghong;
Kang, Jing;
McCreary, Mark;
Modrusan, Zora;
Austin, Cary D.;
Xu, Min;
Brown, Eric J.
Erschienen:
Proceedings of the National Academy of Sciences, 2017
Erschienen in:
Proceedings of the National Academy of Sciences, 114 (2017) 42, Seite 11223-11228
Sprache:
Englisch
DOI:
10.1073/pnas.1700627114
ISSN:
0027-8424;
1091-6490
Entstehung:
Anmerkungen:
Beschreibung:
SignificanceStaphylococcus aureusis one of the most adaptable and prolific human pathogens, and it employs an arsenal of virulence factors to infect blood, bone, and soft tissues. The type VII secretion system (T7SS) is a dedicated virulence protein-secretion pathway that enables long-term survival of the bacteria in abscesses, where they are protected from host immune cells. Here we report that host-derived fatty acids are incorporated into theS.aureusmembrane, altering bacterial membrane properties and activating the expression of the T7SS. Thus, this work identifies a mechanism by which an important human pathogen senses unique elements of the host environment and implements the expression of specific genes that enable bacterial survival and thereby promote human disease.