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Kannan, Meghna; Bayam, Efil; Wagner, Christel; Rinaldi, Bruno; Kretz, Perrine F.; Tilly, Peggy; Roos, Marna; McGillewie, Lara; Bär, Séverine; Minocha, Shilpi; Chevalier, Claire; Po, Chrystelle; Chelly, Jamel; Mandel, Jean-Louis; Borgatti, Renato; Piton, Amélie; Kinnear, Craig; Loos, Ben; Adams, David J.; Hérault, Yann; Collins, Stephan C.; Friant, Sylvie; Godin, Juliette D.; Yalcin, Binnaz; [...]

WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy

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  • Medientyp: E-Artikel
  • Titel: WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy
  • Beteiligte: Kannan, Meghna; Bayam, Efil; Wagner, Christel; Rinaldi, Bruno; Kretz, Perrine F.; Tilly, Peggy; Roos, Marna; McGillewie, Lara; Bär, Séverine; Minocha, Shilpi; Chevalier, Claire; Po, Chrystelle; Chelly, Jamel; Mandel, Jean-Louis; Borgatti, Renato; Piton, Amélie; Kinnear, Craig; Loos, Ben; Adams, David J.; Hérault, Yann; Collins, Stephan C.; Friant, Sylvie; Godin, Juliette D.; Yalcin, Binnaz; [...]
  • Erschienen: Proceedings of the National Academy of Sciences, 2017
  • Erschienen in: Proceedings of the National Academy of Sciences
  • Sprache: Englisch
  • DOI: 10.1073/pnas.1713625114
  • ISSN: 0027-8424; 1091-6490
  • Schlagwörter: Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Significance</jats:title> <jats:p>We present an identification of the relevance of WD40-repeat (WDR) genes in brain connectivity, highlighting the power of unbiased mouse studies in the field of neuroscience. We focus on the poorly studied WDR47 protein sharing structural homology with LIS1, which causes lissencephaly. WDR47 plays a role in progenitor proliferation, neuronal migration, and fiber tract projections in a similar fashion to LIS1 but with the distinctive particularity that WDR47 inhibits autophagic flux. This provides a functional link between autophagy biology and the C-terminal to LisH domain in mammals. Importantly, WDR47 uncovers an aspect of corpus callosum biology pointing toward a link between the regulation of microtubule dynamics and autophagic flux for axonal outgrowth and guidance.</jats:p>
  • Zugangsstatus: Freier Zugang