Dynamic patterns of cortical expansion during folding of the preterm human brain

Medientyp: E-Artikel
Titel: Dynamic patterns of cortical expansion during folding of the preterm human brain
Beteiligte: Garcia, Kara E.; Robinson, Emma C.; Alexopoulos, Dimitrios; Dierker, Donna L.; Glasser, Matthew F.; Coalson, Timothy S.; Ortinau, Cynthia M.; Rueckert, Daniel; Taber, Larry A.; Van Essen, David C.; Rogers, Cynthia E.; Smyser, Christopher D.; Bayly, Philip V.
Erschienen: Proceedings of the National Academy of Sciences, 2018
Erschienen in: Proceedings of the National Academy of Sciences
Sprache: Englisch
DOI: 10.1073/pnas.1715451115
ISSN: 1091-6490; 0027-8424
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Beschreibung: <jats:title>Significance</jats:title> <jats:p>The human brain exhibits complex folding patterns that emerge during the third trimester of fetal development. Minor folds are quasi-randomly shaped and distributed. Major folds, in contrast, are more conserved and form important landmarks. Disruption of cortical folding is associated with devastating disorders of cognition and emotion. Despite decades of study, the processes that produce normal and abnormal folding remain unresolved, although the relatively rapid tangential expansion of the cortex has emerged as a driving factor. Accurate and precise measurement of cortical growth patterns during the period of folding has remained elusive. Here, we illuminate the spatiotemporal dynamics of cortical expansion by analyzing MRI-derived surfaces of preterm infant brains, using a unique strain energy minimization approach.</jats:p>
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