Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle

Medientyp: E-Artikel
Titel: Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle
Beteiligte: Wefers, Jakob; van Moorsel, Dirk; Hansen, Jan; Connell, Niels J.; Havekes, Bas; Hoeks, Joris; van Marken Lichtenbelt, Wouter D.; Duez, Hélène; Phielix, Esther; Kalsbeek, Andries; Boekschoten, Mark V.; Hooiveld, Guido J.; Hesselink, Matthijs K. C.; Kersten, Sander; Staels, Bart; Scheer, Frank A. J. L.; Schrauwen, Patrick
Erschienen: Proceedings of the National Academy of Sciences, 2018
Erschienen in: Proceedings of the National Academy of Sciences
Sprache: Englisch
DOI: 10.1073/pnas.1722295115
ISSN: 1091-6490; 0027-8424
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Beschreibung: <jats:title>Significance</jats:title> <jats:p>Shift workers are affected by circadian misalignment and have an increased risk to develop metabolic diseases such as type 2 diabetes. Here, we show that during simulated short-term night shift work insulin sensitivity at the level of skeletal muscle is decreased in male volunteers, which could contribute to the development of type 2 diabetes in the long term. We also find that the muscle molecular clock does not align rapidly to the new behavioral cycle. Importantly, on the level of the transcriptome, circadian misalignment induced upregulation of fatty acid metabolism pathways, potentially resulting in substrate competition on the cellular level. These findings help to better understand the negative consequences during night shift work.</jats:p>
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