Ivancic, Melanie M.;
Anson, Leigh W.;
Pickhardt, Perry J.;
Megna, Bryant;
Pooler, Bryan D.;
Clipson, Linda;
Reichelderfer, Mark;
Sussman, Michael R.;
Dove, William F.
Conserved serum protein biomarkers associated with growing early colorectal adenomas
Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Conserved serum protein biomarkers associated with growing early colorectal adenomas
Beteiligte:
Ivancic, Melanie M.;
Anson, Leigh W.;
Pickhardt, Perry J.;
Megna, Bryant;
Pooler, Bryan D.;
Clipson, Linda;
Reichelderfer, Mark;
Sussman, Michael R.;
Dove, William F.
Erschienen:
Proceedings of the National Academy of Sciences, 2019
Erschienen in:Proceedings of the National Academy of Sciences
Beschreibung:
<jats:title>Significance</jats:title>
<jats:p>The premalignant colonic adenoma presents a long-lived target to prevent colon cancer. The levels of peptide biomarkers for four serum proteins—F5, ITIH4, LRG1, and VTN—are each elevated in sera in two adenoma-bearing animal models and in patients. The elevated levels of these serum proteins are correlated with total colonic adenoma number in the rat model. Longitudinal analysis of patients demonstrated their association with the subset of adenomas that continue to grow, but not with the total volume of the adenoma burden. This pattern of correlation with the number and growth, but not total adenoma volume, indicates that this class of marker can complement an emergent class of volume-dependent markers to detect the growing early colonic adenoma, minimizing overdiagnosis.</jats:p>