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Unterhauser, Katrin; Pöltl, Lisa; Schneditz, Georg; Kienesberger, Sabine; Glabonjat, Ronald A.; Kitsera, Maksym; Pletz, Jakob; Josa-Prado, Fernando; Dornisch, Elisabeth; Lembacher-Fadum, Christian; Roier, Sandro; Gorkiewicz, Gregor; Lucena, Daniel; Barasoain, Isabel; Kroutil, Wolfgang; Wiedner, Marc; Loizou, Joanna I.; Breinbauer, Rolf; Díaz, José Fernando; Schild, Stefan; Högenauer, Christoph; Zechner, Ellen L.

Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities

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  • Medientyp: E-Artikel
  • Titel: Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities
  • Beteiligte: Unterhauser, Katrin; Pöltl, Lisa; Schneditz, Georg; Kienesberger, Sabine; Glabonjat, Ronald A.; Kitsera, Maksym; Pletz, Jakob; Josa-Prado, Fernando; Dornisch, Elisabeth; Lembacher-Fadum, Christian; Roier, Sandro; Gorkiewicz, Gregor; Lucena, Daniel; Barasoain, Isabel; Kroutil, Wolfgang; Wiedner, Marc; Loizou, Joanna I.; Breinbauer, Rolf; Díaz, José Fernando; Schild, Stefan; Högenauer, Christoph; Zechner, Ellen L.
  • Erschienen: Proceedings of the National Academy of Sciences, 2019
  • Erschienen in: Proceedings of the National Academy of Sciences
  • Sprache: Englisch
  • DOI: 10.1073/pnas.1819154116
  • ISSN: 0027-8424; 1091-6490
  • Schlagwörter: Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Significance</jats:title> <jats:p> Human gut microbes form a complex community with vast biosynthetic potential. Microbial products and metabolites released in the gut impact human health and disease. However, defining causative relationships between specific bacterial products and disease initiation and progression remains an immense challenge. This study advances understanding of the functional capacity of the gut microbiota by determining the presence, concentration, and spatial and temporal variability of two enterotoxic metabolites produced by the gut-resident <jats:italic>Klebsiella oxytoca</jats:italic> . We present a detailed mode of action for the cytotoxins and recapitulate their functionalities in disease models in vivo. The findings provide distinct molecular mechanisms for the enterotoxicity of the metabolites allowing them to act in tandem to damage the intestinal epithelium and cause colitis. </jats:p>
  • Zugangsstatus: Freier Zugang