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Medientyp:
E-Artikel
Titel:
Leptin’s hunger-suppressing effects are mediated by the hypothalamic–pituitary–adrenocortical axis in rodents
Beteiligte:
Perry, Rachel J.;
Resch, Jon M.;
Douglass, Amelia M.;
Madara, Joseph C.;
Rabin-Court, Aviva;
Kucukdereli, Hakan;
Wu, Chen;
Song, Joongyu D.;
Lowell, Bradford B.;
Shulman, Gerald I.
Erschienen:
Proceedings of the National Academy of Sciences, 2019
Erschienen in:
Proceedings of the National Academy of Sciences, 116 (2019) 27, Seite 13670-13679
Sprache:
Englisch
DOI:
10.1073/pnas.1901795116
ISSN:
0027-8424;
1091-6490
Entstehung:
Anmerkungen:
Beschreibung:
Significance Low levels of leptin, a hormone secreted by adipocytes that signals the body as to the availability of fuel stores, are known to increase food intake. Here, we demonstrate a mechanism by which low leptin stimulates food intake in rodents: Under conditions of hypoleptinemia, stress hormone (glucocorticoid) production is increased, and in turn stimulates AgRP neurons to promote appetite.