Exquisite sensitivity of adrenocortical carcinomas to induction of ferroptosis

Medientyp: E-Artikel
Titel: Exquisite sensitivity of adrenocortical carcinomas to induction of ferroptosis
Beteiligte: Belavgeni, Alexia; Bornstein, Stefan R.; von Mässenhausen, Anne; Tonnus, Wulf; Stumpf, Julian; Meyer, Claudia; Othmar, Evelyn; Latk, Markus; Kanczkowski, Waldemar; Kroiss, Matthias; Hantel, Constanze; Hugo, Christian; Fassnacht, Martin; Ziegler, Christian G.; Schally, Andrew V.; Krone, Nils P.; Linkermann, Andreas
Erschienen: Proceedings of the National Academy of Sciences, 2019
Erschienen in: Proceedings of the National Academy of Sciences, 116 (2019) 44, Seite 22269-22274
Sprache: Englisch
DOI: 10.1073/pnas.1912700116
ISSN: 1091-6490; 0027-8424
Schlagwörter: Multidisciplinary
Entstehung:
Anmerkungen:
Beschreibung: <jats:title>Significance</jats:title> <jats:p>The currently used treatment regimen for the cancers of the adrenal cortex involves mitotane, a nonspecific derivative of the pesticide DDT (1,1-(dichlorobiphenyl)-2,2-dichloroethane), which has an unclear mechanism of action. Our studies in cell culture and genetic analysis of public databases demonstrate that human adrenocortical carcinomas (ACCs) are remarkably sensitive to a recently defined cell death pathway referred to as ferroptosis, indicating that induction of ferroptosis could be a promising treatment approach for ACCs. However, mitotane does not induce ferroptosis. Given the untoward side effect profile of mitotane, we suggest that ferroptosis-inducing agents may represent a more specific, more potent, and less toxic approach to treatment for patients with ACC than mitotane.</jats:p>
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