Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Sex differences in the circadian misalignment effects on energy regulation
Beteiligte:
Qian, Jingyi;
Morris, Christopher J.;
Caputo, Rosanna;
Wang, Wei;
Garaulet, Marta;
Scheer, Frank A. J. L.
Erschienen:
Proceedings of the National Academy of Sciences, 2019
Erschienen in:Proceedings of the National Academy of Sciences
Sprache:
Englisch
DOI:
10.1073/pnas.1914003116
ISSN:
0027-8424;
1091-6490
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Significance</jats:title>
<jats:p>Shift workers frequently experience circadian misalignment and are at increased risks of obesity. It is established that some characteristics of the circadian system and body weight regulation differ between males and females. However, whether there are sex differences in the effects of circadian misalignment on energy regulation remains unknown. Here we show that circadian misalignment disrupts energy balance in females and males through different pathways. Females had more disturbances in the energy homeostasis process, including a decrease in the satiety hormone and an increase in hunger hormone. Males had elevated cravings for energy-dense and savory foods. These data have potential implications for sex-specific weight gain prevention in shift work populations and other groups experiencing circadian rhythm disturbances.</jats:p>