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Medientyp:
E-Artikel
Titel:
β2 Integrins differentially regulate γδ T cell subset thymic development and peripheral maintenance
Beteiligte:
McIntyre, Claire L.;
Monin, Leticia;
Rop, Jesse C.;
Otto, Thomas D.;
Goodyear, Carl S.;
Hayday, Adrian C.;
Morrison, Vicky L.
Erschienen:
Proceedings of the National Academy of Sciences, 2020
Erschienen in:
Proceedings of the National Academy of Sciences, 117 (2020) 36, Seite 22367-22377
Sprache:
Englisch
DOI:
10.1073/pnas.1921930117
ISSN:
0027-8424;
1091-6490
Entstehung:
Anmerkungen:
Beschreibung:
Significance γδ T cells reside in barrier tissues and provide immune protection against infection and cancer. Their antitumor potential has led to recent advances in the development of γδ T cell immunotherapy. However, our understanding of the basic biology of these cells, including which molecules and pathways control their maintenance within barrier tissues, remains poor. We demonstrate that β 2 integrin adhesion molecules play a major role in regulating γδ T cell subset numbers during homeostasis: the loss of β 2 integrin expression results in a striking increase in IL-17–producing γδ T cells in the lungs and uterus due to enhanced survival. These findings illustrate a mechanism of γδ T cell regulation that may have significant implications for immunotherapy development.