Erschienen:
Proceedings of the National Academy of Sciences, 2013
Erschienen in:Proceedings of the National Academy of Sciences
Sprache:
Englisch
DOI:
10.1073/pnas.1311725110
ISSN:
0027-8424;
1091-6490
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Significance</jats:title>
<jats:p>
Bacterial pathogens use multiple mechanisms to survive and proliferate within an infected host, including blunting the host’s ability to defend itself from pathogenic assaults. We identified a new immune suppression mechanism by
<jats:italic>Burkholderia pseudomallei</jats:italic>
, the causative agent of melioidosis, which a life-threatening disease in humans. Analyses of whole-genome transcriptional responses of
<jats:italic>Caenorhabditis elegans</jats:italic>
to
<jats:italic>B. pseudomallei</jats:italic>
infection revealed that
<jats:italic>B. pseudomallei</jats:italic>
, through its type III secretion system, recruits the host ubiquitin–proteasome system to specifically degrade a GATA transcription factor. This GATA factor is critical for host immune defense; thus, its degradation leads to suppression of the host’s ability to mount an effective antimicrobial defense.
</jats:p>