> Detailanzeige
Morikawa, Hiromasa;
Ohkura, Naganari;
Vandenbon, Alexis;
Itoh, Masayoshi;
Nagao-Sato, Sayaka;
Kawaji, Hideya;
Lassmann, Timo;
Carninci, Piero;
Hayashizaki, Yoshihide;
Forrest, Alistair R. R.;
Standley, Daron M.;
Date, Hiroshi;
Sakaguchi, Shimon;
Forrest, Alistair R.R.;
Kawaji, Hideya;
Rehli, Michael;
Baillie, J. Kenneth;
de Hoon, Michiel J.L.;
Haberle, Vanja;
Lassmann, Timo;
Kulakovskiy, Ivan V.;
Lizio, Marina;
Itoh, Masayoshi;
Andersson, Robin;
[...]
Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation
Teilen
Literatur-
verwaltung
Direktlink
Zur
Merkliste
Lösche von
Merkliste
Per Email teilen
Auf Twitter teilen
Auf Facebook teilen
Per Whatsapp teilen
- Medientyp: E-Artikel
- Titel: Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation
- Beteiligte: Morikawa, Hiromasa; Ohkura, Naganari; Vandenbon, Alexis; Itoh, Masayoshi; Nagao-Sato, Sayaka; Kawaji, Hideya; Lassmann, Timo; Carninci, Piero; Hayashizaki, Yoshihide; Forrest, Alistair R. R.; Standley, Daron M.; Date, Hiroshi; Sakaguchi, Shimon; Forrest, Alistair R.R.; Kawaji, Hideya; Rehli, Michael; Baillie, J. Kenneth; de Hoon, Michiel J.L.; Haberle, Vanja; Lassmann, Timo; Kulakovskiy, Ivan V.; Lizio, Marina; Itoh, Masayoshi; Andersson, Robin; [...]
-
Erschienen:
Proceedings of the National Academy of Sciences, 2014
- Erschienen in: Proceedings of the National Academy of Sciences
- Sprache: Englisch
- DOI: 10.1073/pnas.1312717110
- ISSN: 0027-8424; 1091-6490
- Entstehung:
- Anmerkungen:
- Beschreibung: <jats:p>Naturally occurring regulatory T (Treg) cells, which specifically express the transcription factor forkhead box P3 (Foxp3), are engaged in the maintenance of immunological self-tolerance and homeostasis. By transcriptional start site cluster analysis, we assessed here how genome-wide patterns of DNA methylation or Foxp3 binding sites were associated with Treg-specific gene expression. We found that Treg-specific DNA hypomethylated regions were closely associated with Treg up-regulated transcriptional start site clusters, whereas Foxp3 binding regions had no significant correlation with either up- or down-regulated clusters in nonactivated Treg cells. However, in activated Treg cells, Foxp3 binding regions showed a strong correlation with down-regulated clusters. In accordance with these findings, the above two features of activation-dependent gene regulation in Treg cells tend to occur at different locations in the genome. The results collectively indicate that Treg-specific DNA hypomethylation is instrumental in gene up-regulation in steady state Treg cells, whereas Foxp3 down-regulates the expression of its target genes in activated Treg cells. Thus, the two events seem to play distinct but complementary roles in Treg-specific gene expression.</jats:p>
- Zugangsstatus: Freier Zugang