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Medientyp:
E-Artikel
Titel:
Multiple epithelia are required to develop teeth deep inside the pharynx
Beteiligte:
Oralová, Veronika;
Rosa, Joana Teixeira;
Larionova, Daria;
Witten, P. Eckhard;
Huysseune, Ann
Erschienen:
Proceedings of the National Academy of Sciences, 2020
Erschienen in:
Proceedings of the National Academy of Sciences, 117 (2020) 21, Seite 11503-11512
Sprache:
Englisch
DOI:
10.1073/pnas.2000279117
ISSN:
0027-8424;
1091-6490
Entstehung:
Anmerkungen:
Beschreibung:
Significance Many vertebrates possess teeth deep in the pharynx. While teeth are known to derive from odontodes (skin denticles), it is unknown if an external epithelium is still required to produce a pharyngeal tooth, such as for odontode formation. Here, we show that the epithelial enamel organ of pharyngeal teeth in zebrafish is formed from endoderm, i.e. the internal germ layer. However, teeth develop 1) only when this endoderm becomes covered by a layer of cells with features of a periderm, i.e., the outer epithelial covering of the embryo; and 2) only when the endoderm has physically contacted the skin at the prospective gill slits. Thus, multiple epithelia are engaged in tooth formation, whether oral (mammals) or pharyngeal (teleosts).