Erschienen:
Proceedings of the National Academy of Sciences, 2021
Erschienen in:
Proceedings of the National Academy of Sciences, 118 (2021) 18
Sprache:
Englisch
DOI:
10.1073/pnas.2014472118
ISSN:
0027-8424;
1091-6490
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Significance</jats:title>
<jats:p>For the development of gene therapy and optical cochlear implants (oCI), detailed knowledge of the cochlear morphology is crucial. Here, we employed multiscale X-ray and fluorescence imaging for quantitative assessment of scala tympani, vestibuli, and media, as well as the spiral ganglion in Rosenthal’s canal for various species commonly used in auditory research. Furthermore, we demonstrate the feasibility of oCI implantation for rodents and marmosets, as a nonhuman primate model. Using modeling of light propagation from the emitters of the oCI, we estimate the frequency selectivity and range covered by optical stimulation within the cochlea.</jats:p>