Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity

Medientyp: E-Artikel
Titel: Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity
Beteiligte: Kvedaraite, Egle; Hertwig, Laura; Sinha, Indranil; Ponzetta, Andrea; Hed Myrberg, Ida; Lourda, Magda; Dzidic, Majda; Akber, Mira; Klingström, Jonas; Folkesson, Elin; Muvva, Jagadeeswara Rao; Chen, Puran; Gredmark-Russ, Sara; Brighenti, Susanna; Norrby-Teglund, Anna; Eriksson, Lars I.; Rooyackers, Olav; Aleman, Soo; Strålin, Kristoffer; Ljunggren, Hans-Gustaf; Ginhoux, Florent; Björkström, Niklas K.; Henter, Jan-Inge; Svensson, Mattias; [...]
Erschienen: Proceedings of the National Academy of Sciences, 2021
Erschienen in: Proceedings of the National Academy of Sciences
Sprache: Englisch
DOI: 10.1073/pnas.2018587118
ISSN: 0027-8424; 1091-6490
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Beschreibung: <jats:title>Significance</jats:title> <jats:p>While broad efforts toward getting an overview of immune cell and soluble factor alterations in COVID-19 are under way, a deep and comprehensive understanding of the mononuclear phagocyte system, including circulating progenitors, is still largely lacking. This study provides a reference for the mononuclear phagocyte response to SARS-CoV-2 infection and unravels mononuclear phagocyte dysregulations associated with severe COVID-19.</jats:p>
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