In vivo imaging of nanoparticle-labeled CAR T cells

Medientyp: E-Artikel
Titel: In vivo imaging of nanoparticle-labeled CAR T cells
Beteiligte: Kiru, Louise; Zlitni, Aimen; Tousley, Aidan Michael; Dalton, Guillermo Nicolás; Wu, Wei; Lafortune, Famyrah; Liu, Anna; Cunanan, Kristen May; Nejadnik, Hossein; Sulchek, Todd; Moseley, Michael Eugene; Majzner, Robbie G.; Daldrup-Link, Heike Elisabeth
Erschienen: Proceedings of the National Academy of Sciences, 2022
Erschienen in: Proceedings of the National Academy of Sciences
Sprache: Englisch
DOI: 10.1073/pnas.2102363119
ISSN: 0027-8424; 1091-6490
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Beschreibung: <jats:title>Significance</jats:title> <jats:p>Chimeric antigen receptor (CAR) T-cell therapy is approved by the US Food and Drug Administration (FDA) for the treatment of B-cell acute lymphoblastic leukemia. Efforts are now underway to evaluate the efficacy of CAR T-cell therapy in solid tumors. However, a key limitation in the advancement of T-cell therapy is the lack of information on the biodistribution of the T cells in patients. Therefore, there is a need for the identification of translatable methods for tracking the therapeutic T cells noninvasively. We describe the mechanical labeling of CAR T cells with an FDA-approved iron oxide nanoparticle to demonstrate the noninvasive and multimodal imaging of the CAR T cells. This method may be utilized for monitoring T cells in clinical trials.</jats:p>
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