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King, Hannah A. D.; Joyce, M. Gordon; Lakhal-Naouar, Ines; Ahmed, Aslaa; Cincotta, Camila Macedo; Subra, Caroline; Peachman, Kristina K.; Hack, Holly R.; Chen, Rita E.; Thomas, Paul V.; Chen, Wei-Hung; Sankhala, Rajeshwer S.; Hajduczki, Agnes; Martinez, Elizabeth J.; Peterson, Caroline E.; Chang, William C.; Choe, Misook; Smith, Clayton; Headley, Jarrett A.; Elyard, Hanne A.; Cook, Anthony; Anderson, Alexander; Wuertz, Kathryn McGuckin; Dong, Ming; [...]

Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

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  • Medientyp: E-Artikel
  • Titel: Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques
  • Beteiligte: King, Hannah A. D.; Joyce, M. Gordon; Lakhal-Naouar, Ines; Ahmed, Aslaa; Cincotta, Camila Macedo; Subra, Caroline; Peachman, Kristina K.; Hack, Holly R.; Chen, Rita E.; Thomas, Paul V.; Chen, Wei-Hung; Sankhala, Rajeshwer S.; Hajduczki, Agnes; Martinez, Elizabeth J.; Peterson, Caroline E.; Chang, William C.; Choe, Misook; Smith, Clayton; Headley, Jarrett A.; Elyard, Hanne A.; Cook, Anthony; Anderson, Alexander; Wuertz, Kathryn McGuckin; Dong, Ming; [...]
  • Erschienen: Proceedings of the National Academy of Sciences, 2021
  • Erschienen in: Proceedings of the National Academy of Sciences
  • Sprache: Englisch
  • DOI: 10.1073/pnas.2106433118
  • ISSN: 0027-8424; 1091-6490
  • Schlagwörter: Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Significance</jats:title> <jats:p> The emergence of SARS-CoV-2 variants of concern (VOCs) that reduce the efficacy of current COVID-19 vaccines is a major threat to pandemic control. We evaluate a SARS-CoV-2 spike receptor-binding domain ferritin nanoparticle protein vaccine (RFN) in a nonhuman primate challenge model that addresses the need for a next-generation vaccine with increased pan-SARS breadth of coverage. RFN, adjuvanted with a liposomal-QS21 formulation (ALFQ), elicits humoral and cellular immune responses with excellent breadth and potency against SARS-CoV-2 VOCs and SARS-CoV-1, and protects against high-dose respiratory tract challenge with SARS-CoV-2. Our results support consideration of RFN for vaccine development against multiple concerning members of the Sarbecovirus subgenus of <jats:italic>Betacoronaviruses</jats:italic> . </jats:p>
  • Zugangsstatus: Freier Zugang