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Bertram, Tabea; Reimers, Daniel; Lory, Niels C.; Schmidt, Constantin; Schmid, Joanna; C. Heinig, Lisa; Bradtke, Peter; Rattay, Guido; Zielinski, Stephanie; Hellmig, Malte; Bartsch, Patricia; Rohde, Holger; Nuñez, Sarah; Rosemblatt, Mariana V.; Bono, Maria Rosa; Gagliani, Nicola; Sandrock, Inga; Panzer, Ulf; Krebs, Christian F.; Meyer-Schwesinger, Catherine; Prinz, Immo; Mittrücker, Hans-Willi

Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice

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  • Medientyp: E-Artikel
  • Titel: Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice
  • Beteiligte: Bertram, Tabea; Reimers, Daniel; Lory, Niels C.; Schmidt, Constantin; Schmid, Joanna; C. Heinig, Lisa; Bradtke, Peter; Rattay, Guido; Zielinski, Stephanie; Hellmig, Malte; Bartsch, Patricia; Rohde, Holger; Nuñez, Sarah; Rosemblatt, Mariana V.; Bono, Maria Rosa; Gagliani, Nicola; Sandrock, Inga; Panzer, Ulf; Krebs, Christian F.; Meyer-Schwesinger, Catherine; Prinz, Immo; Mittrücker, Hans-Willi
  • Erschienen: Proceedings of the National Academy of Sciences, 2023
  • Erschienen in: Proceedings of the National Academy of Sciences
  • Sprache: Englisch
  • DOI: 10.1073/pnas.2210490120
  • ISSN: 0027-8424; 1091-6490
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p> γδ T cells are involved in the control of <jats:italic>Staphylococcus aureus</jats:italic> infection, but their importance in protection compared to other T cells is unclear. We used a mouse model of systemic <jats:italic>S. aureus</jats:italic> infection associated with high bacterial load and persistence in the kidney. Infection caused fulminant accumulation of γδ T cells in the kidney. Renal γδ T cells acquired tissue residency and were maintained in high numbers during chronic infection. At day 7, up to 50% of renal γδ T cells produced IL-17A in situ and a large fraction of renal γδ T cells remained IL-17A <jats:sup>+</jats:sup> during chronic infection. Controlled depletion revealed that γδ T cells restricted renal <jats:italic>S. aureus</jats:italic> replication in the acute infection and provided protection during chronic renal infection and upon reinfection. Our results demonstrate that kidney-resident γδ T cells are nonredundant in limiting local <jats:italic>S. aureus</jats:italic> growth during chronic infection and provide enhanced protection against reinfection. </jats:p>
  • Zugangsstatus: Freier Zugang