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Medientyp:
E-Artikel
Titel:
On the attribution and additivity of binding energies
Beteiligte:
Jencks, William P.
Erschienen:
Proceedings of the National Academy of Sciences, 1981
Erschienen in:Proceedings of the National Academy of Sciences
Sprache:
Englisch
DOI:
10.1073/pnas.78.7.4046
ISSN:
0027-8424;
1091-6490
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>
It can be useful to describe the Gibbs free energy changes for the binding to a protein of a molecule, A—B, and of its component parts, A and B, in terms of the “intrinsic binding energies” of A and B, Δ
<jats:italic>G</jats:italic>
<jats:sub>A</jats:sub>
<jats:sup>i</jats:sup>
and Δ
<jats:italic>G</jats:italic>
<jats:sub>B</jats:sub>
<jats:sup>i</jats:sup>
, and a “connection Gibbs energy,” Δ
<jats:italic>G</jats:italic>
<jats:sup>s</jats:sup>
that is derived largely from changes in translational and rotational entropy. This empirical approach avoids the difficult or insoluble problem of interpreting observed ΔH and
<jats:italic>T</jats:italic>
Δ
<jats:italic>S</jats:italic>
values for aqueous solutions. The Δ
<jats:italic>G</jats:italic>
<jats:sup>i</jats:sup>
and Δ
<jats:italic>G</jats:italic>
<jats:sup>s</jats:sup>
terms can be large for binding to enzymes and other proteins.
</jats:p>