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Medientyp:
E-Artikel
Titel:
A homeostatic clock sets daughter centriole size in flies
Beteiligte:
Aydogan, Mustafa G.;
Wainman, Alan;
Saurya, Saroj;
Steinacker, Thomas L.;
Caballe, Anna;
Novak, Zsofia A.;
Baumbach, Janina;
Muschalik, Nadine;
Raff, Jordan W.
Erschienen:
Rockefeller University Press, 2018
Erschienen in:
Journal of Cell Biology, 217 (2018) 4, Seite 1233-1248
Sprache:
Englisch
DOI:
10.1083/jcb.201801014
ISSN:
0021-9525;
1540-8140
Entstehung:
Anmerkungen:
Beschreibung:
Centrioles are highly structured organelles whose size is remarkably consistent within any given cell type. New centrioles are born when Polo-like kinase 4 (Plk4) recruits Ana2/STIL and Sas-6 to the side of an existing “mother” centriole. These two proteins then assemble into a cartwheel, which grows outwards to form the structural core of a new daughter. Here, we show that in early Drosophila melanogaster embryos, daughter centrioles grow at a linear rate during early S-phase and abruptly stop growing when they reach their correct size in mid- to late S-phase. Unexpectedly, the cartwheel grows from its proximal end, and Plk4 determines both the rate and period of centriole growth: the more active the centriolar Plk4, the faster centrioles grow, but the faster centriolar Plk4 is inactivated and growth ceases. Thus, Plk4 functions as a homeostatic clock, establishing an inverse relationship between growth rate and period to ensure that daughter centrioles grow to the correct size.