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Becerra-Muñoz, Víctor Manuel; Núñez-Gil, Iván J; Eid, Charbel Maroun; García Aguado, Marcos; Romero, Rodolfo; Huang, Jia; Mulet, Alba; Ugo, Fabrizio; Rametta, Francesco; Liebetrau, Christoph; Aparisi, Alvaro; Fernández-Rozas, Inmaculada; Viana-Llamas, María C; Feltes, Gisela; Pepe, Martino; Moreno-Rondón, Luis A; Cerrato, Enrico; Raposeiras-Roubín, Sergio; Alfonso, Emilio; Carrero-Fernández, Ana; Buzón-Martín, Luis; Abumayyaleh, Mohammad; Gonzalez, Adelina; Fernández Ortiz, Antonio; [...]

Clinical profile and predictors of in-hospital mortality among older patients hospitalised for COVID-19

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  • Medientyp: E-Artikel
  • Titel: Clinical profile and predictors of in-hospital mortality among older patients hospitalised for COVID-19
  • Beteiligte: Becerra-Muñoz, Víctor Manuel; Núñez-Gil, Iván J; Eid, Charbel Maroun; García Aguado, Marcos; Romero, Rodolfo; Huang, Jia; Mulet, Alba; Ugo, Fabrizio; Rametta, Francesco; Liebetrau, Christoph; Aparisi, Alvaro; Fernández-Rozas, Inmaculada; Viana-Llamas, María C; Feltes, Gisela; Pepe, Martino; Moreno-Rondón, Luis A; Cerrato, Enrico; Raposeiras-Roubín, Sergio; Alfonso, Emilio; Carrero-Fernández, Ana; Buzón-Martín, Luis; Abumayyaleh, Mohammad; Gonzalez, Adelina; Fernández Ortiz, Antonio; [...]
  • Erschienen: Oxford University Press (OUP), 2021
  • Erschienen in: Age and Ageing
  • Sprache: Englisch
  • DOI: 10.1093/ageing/afaa258
  • ISSN: 0002-0729; 1468-2834
  • Schlagwörter: Geriatrics and Gerontology ; Aging ; General Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>the coronavirus disease 2019 (COVID-19) is characterized by poor outcomes and mortality, particularly in older patients.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>post hoc analysis of the international, multicentre, ‘real-world’ HOPE COVID-19 registry. All patients aged ≥65 years hospitalised for COVID-19 were selected. Epidemiological, clinical, analytical and outcome data were obtained. A comparative study between two age subgroups, 65–74 and ≥75 years, was performed. The primary endpoint was all cause in-hospital mortality.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>about, 1,520 patients aged ≥65 years (60.3% male, median age of 76 [IQR 71–83] years) were included. Comorbidities such as hypertension (69.2%), dyslipidaemia (48.6%), cardiovascular diseases (any chronic heart disease in 38.4% and cerebrovascular disease in 12.5%), and chronic lung disease (25.3%) were prevalent, and 49.6% were on ACEI/ARBs. Patients aged 75 years and older suffered more in-hospital complications (respiratory failure, heart failure, renal failure, sepsis) and a significantly higher mortality (18.4 vs. 48.2%, P &amp;lt; 0.001), but fewer admissions to intensive care units (11.2 vs. 4.8%). In the overall cohort, multivariable analysis demonstrated age ≥75 (OR 3.54), chronic kidney disease (OR 3.36), dementia (OR 8.06), peripheral oxygen saturation at admission &amp;lt;92% (OR 5.85), severe lymphopenia (&amp;lt;500/mm3) (OR 3.36) and qSOFA (Quick Sequential Organ Failure Assessment Score) &amp;gt;1 (OR 8.31) to be independent predictors of mortality.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>patients aged ≥65 years hospitalised for COVID-19 had high rates of in-hospital complications and mortality, especially among patients 75 years or older. Age ≥75 years, dementia, peripheral oxygen saturation &amp;lt;92%, severe lymphopenia and qSOFA scale &amp;gt;1 were independent predictors of mortality in this population.</jats:p> </jats:sec>
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