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Girmenia, Corrado;
Bertaina, Alice;
Piciocchi, Alfonso;
Perruccio, Katia;
Algarotti, Alessandra;
Busca, Alessandro;
Cattaneo, Chiara;
Raiola, Anna Maria;
Guidi, Stefano;
Iori, Anna Paola;
Candoni, Anna;
Irrera, Giuseppe;
Milone, Giuseppe;
Marcacci, Giampaolo;
Scimè, Rosanna;
Musso, Maurizio;
Cudillo, Laura;
Sica, Simona;
Castagna, Luca;
Corradini, Paolo;
Marchesi, Francesco;
Pastore, Domenico;
Alessandrino, Emilio Paolo;
Annaloro, Claudio;
[...]
Incidence, Risk Factors and Outcome of Pre-engraftment Gram-Negative Bacteremia After Allogeneic and Autologous Hematopoietic Stem Cell Transplantation: An Italian Prospective Multicenter Survey
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- Medientyp: E-Artikel
- Titel: Incidence, Risk Factors and Outcome of Pre-engraftment Gram-Negative Bacteremia After Allogeneic and Autologous Hematopoietic Stem Cell Transplantation: An Italian Prospective Multicenter Survey
- Beteiligte: Girmenia, Corrado; Bertaina, Alice; Piciocchi, Alfonso; Perruccio, Katia; Algarotti, Alessandra; Busca, Alessandro; Cattaneo, Chiara; Raiola, Anna Maria; Guidi, Stefano; Iori, Anna Paola; Candoni, Anna; Irrera, Giuseppe; Milone, Giuseppe; Marcacci, Giampaolo; Scimè, Rosanna; Musso, Maurizio; Cudillo, Laura; Sica, Simona; Castagna, Luca; Corradini, Paolo; Marchesi, Francesco; Pastore, Domenico; Alessandrino, Emilio Paolo; Annaloro, Claudio; [...]
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Erschienen:
Oxford University Press (OUP), 2017
- Erschienen in: Clinical Infectious Diseases
- Sprache: Englisch
- DOI: 10.1093/cid/cix690
- ISSN: 1058-4838; 1537-6591
- Entstehung:
- Anmerkungen:
- Beschreibung: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Gram-negative bacteremia (GNB) is a major cause of illness and death after hematopoietic stem cell transplantation (HSCT), and updated epidemiological investigation is advisable.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>We prospectively evaluated the epidemiology of pre-engraftment GNB in 1118 allogeneic HSCTs (allo-HSCTs) and 1625 autologous HSCTs (auto-HSCTs) among 54 transplant centers during 2014 (SIGNB-GITMO-AMCLI study). Using logistic regression methods. we identified risk factors for GNB and evaluated the impact of GNB on the 4-month overall-survival after transplant.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>The cumulative incidence of pre-engraftment GNB was 17.3% in allo-HSCT and 9% in auto-HSCT. Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa were the most common isolates. By multivariate analysis, variables associated with GNB were a diagnosis of acute leukemia, a transplant from a HLA-mismatched donor and from cord blood, older age, and duration of severe neutropenia in allo-HSCT, and a diagnosis of lymphoma, older age, and no antibacterial prophylaxis in auto-HSCT. A pretransplant infection by a resistant pathogen was significantly associated with an increased risk of posttransplant infection by the same microorganism in allo-HSCT. Colonization by resistant gram-negative bacteria was significantly associated with an increased rate of infection by the same pathogen in both transplant procedures. GNB was independently associated with increased mortality at 4 months both in allo-HSCT (hazard ratio, 2.13; 95% confidence interval, 1.45–3.13; P <.001) and auto-HSCT (2.43; 1.22–4.84; P = .01).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Pre-engraftment GNB is an independent factor associated with increased mortality rate at 4 months after auto-HSCT and allo-HSCT. Previous infectious history and colonization monitoring represent major indicators of GNB.</jats:p> </jats:sec> <jats:sec> <jats:title>Clinical Trials registration</jats:title> <jats:p>NCT02088840.</jats:p> </jats:sec>
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