> Detailanzeige

Dawood, Fatimah S; Naleway, Allison L; Flannery, Brendan; Levine, Min Z; Murthy, Kempapura; Sambhara, Suryaprakash; Gangappa, Shivaprakash; Edwards, Laura; Ball, Sarah; Grant, Lauren; Belongia, Edward; Bounds, Kelsey; Cao, Weiping; Gross, F Liaini; Groom, Holly; Fry, Alicia M; Rentz Hunt, Danielle; Jeddy, Zuha; Mishina, Margarita; Kim, Sara S; Wesley, Meredith G; Spencer, Sarah; Thompson, Mark G; Gaglani, Manjusha

Comparison of the Immunogenicity of Cell Culture-Based and Recombinant Quadrivalent Influenza Vaccines to Conventional Egg-Based Quadrivalent Influenza Vaccines Among Healthcare Personnel Aged 18–64 Years: A Randomized Open-Label Trial

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Comparison of the Immunogenicity of Cell Culture-Based and Recombinant Quadrivalent Influenza Vaccines to Conventional Egg-Based Quadrivalent Influenza Vaccines Among Healthcare Personnel Aged 18–64 Years: A Randomized Open-Label Trial
  • Beteiligte: Dawood, Fatimah S; Naleway, Allison L; Flannery, Brendan; Levine, Min Z; Murthy, Kempapura; Sambhara, Suryaprakash; Gangappa, Shivaprakash; Edwards, Laura; Ball, Sarah; Grant, Lauren; Belongia, Edward; Bounds, Kelsey; Cao, Weiping; Gross, F Liaini; Groom, Holly; Fry, Alicia M; Rentz Hunt, Danielle; Jeddy, Zuha; Mishina, Margarita; Kim, Sara S; Wesley, Meredith G; Spencer, Sarah; Thompson, Mark G; Gaglani, Manjusha
  • Erschienen: Oxford University Press (OUP), 2021
  • Erschienen in: Clinical Infectious Diseases
  • Sprache: Englisch
  • DOI: 10.1093/cid/ciab566
  • ISSN: 1058-4838; 1537-6591
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>RIV4 and cell-culture based inactivated influenza vaccine (ccIIV4) have not been compared to egg-based IIV4 in healthcare personnel, a population with frequent influenza vaccination that may blunt vaccine immune responses over time. We conducted a randomized trial among healthcare personnel (HCP) aged 18–64 years to compare humoral immune responses to ccIIV4 and RIV4 to IIV4.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>During the 2018–2019 season, participants were randomized to receive ccIIV4, RIV4, or IIV4 and had serum samples collected prevaccination, 1 and 6 months postvaccination. Serum samples were tested by hemagglutination inhibition (HI) for influenza A/H1N1, B/Yamagata, and B/Victoria and microneutralization (MN) for A/H3N2 against cell-grown vaccine reference viruses. Primary outcomes at 1 month were seroconversion rate (SCR), geometric mean titers (GMT), GMT ratio, and mean fold rise (MFR) in the intention-to-treat population.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>In total, 727 participants were included (283 ccIIV4, 202 RIV4, and 242 IIV4). At 1 month, responses to ccIIV4 were similar to IIV4 by SCR, GMT, GMT ratio, and MFR. RIV4 induced higher SCRs, GMTs, and MFRs than IIV4 against A/H1N1, A/H3N2, and B/Yamagata. The GMT ratio of RIV4 to egg-based vaccines was 1.5 (95% confidence interval [CI] 1.2–1.9) for A/H1N1, 3.0 (95% CI: 2.4–3.7) for A/H3N2, 1.1 (95% CI: .9–1.4) for B/Yamagata, and 1.1 (95% CI: .9–1.3) for B/Victoria. At 6 months, ccIIV4 recipients had similar GMTs to IIV4, whereas RIV4 recipients had higher GMTs against A/H3N2 and B/Yamagata.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>RIV4 resulted in improved antibody responses by HI and MN compared to egg-based vaccines against 3 of 4 cell-grown vaccine strains 1 month postvaccination, suggesting a possible additional benefit from RIV4.</jats:p> </jats:sec> <jats:sec> <jats:title>Clinical Trials Registration</jats:title> <jats:p>NCT03722589.</jats:p> </jats:sec>
  • Zugangsstatus: Freier Zugang