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Miller, Maureen J; Himschoot, Austin; Fitch, Natalie; Jawalkar, Sucheta; Freeman, Dane; Hilton, Charity; Berney, Kevin; Guy, Gery P; Benoit, Tina J; Clarke, Kristie E N; Busch, Michael P; Opsomer, Jean D; Stramer, Susan L; Hall, Aron J; Gundlapalli, Adi V; MacNeil, Adam; McCord, Russell; Sunshine, Gregory; Howard-Williams, Mara; Dunphy, Christopher; Jones, Jefferson M

Association of Trends in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Seroprevalence and State-Issued Nonpharmaceutical Interventions: United States, 1 August 2020 to 30 March 2021

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  • Medientyp: E-Artikel
  • Titel: Association of Trends in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Seroprevalence and State-Issued Nonpharmaceutical Interventions: United States, 1 August 2020 to 30 March 2021
  • Beteiligte: Miller, Maureen J; Himschoot, Austin; Fitch, Natalie; Jawalkar, Sucheta; Freeman, Dane; Hilton, Charity; Berney, Kevin; Guy, Gery P; Benoit, Tina J; Clarke, Kristie E N; Busch, Michael P; Opsomer, Jean D; Stramer, Susan L; Hall, Aron J; Gundlapalli, Adi V; MacNeil, Adam; McCord, Russell; Sunshine, Gregory; Howard-Williams, Mara; Dunphy, Christopher; Jones, Jefferson M
  • Erschienen: Oxford University Press (OUP), 2022
  • Erschienen in: Clinical Infectious Diseases
  • Sprache: Englisch
  • DOI: 10.1093/cid/ciac469
  • ISSN: 1058-4838; 1537-6591
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>We assess if state-issued nonpharmaceutical interventions (NPIs) are associated with reduced rates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection as measured through anti-nucleocapsid (anti-N) seroprevalence, a proxy for cumulative prior infection that distinguishes seropositivity from vaccination.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Monthly anti-N seroprevalence during 1 August 2020 to 30 March 2021 was estimated using a nationwide blood donor serosurvey. Using multivariable logistic regression models, we measured the association of seropositivity and state-issued, county-specific NPIs for mask mandates, gathering bans, and bar closures.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Compared with individuals living in a county with all three NPIs in place, the odds of having anti-N antibodies were 2.2 (95% confidence interval [CI]: 2.0–2.3) times higher for people living in a county that did not have any of the 3 NPIs, 1.6 (95% CI: 1.5–1.7) times higher for people living in a county that only had a mask mandate and gathering ban policy, and 1.4 (95% CI: 1.3–1.5) times higher for people living in a county that had only a mask mandate.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Consistent with studies assessing NPIs relative to COVID-19 incidence and mortality, the presence of NPIs were associated with lower SARS-CoV-2 seroprevalence indicating lower rates of cumulative infections. Multiple NPIs are likely more effective than single NPIs.</jats:p> </jats:sec>
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