Antibody status and cumulative incidence of SARS-CoV-2 infection among adults in three regions of France following the first lockdown and associated risk factors: a multicohort study

Medientyp: E-Artikel
Titel: Antibody status and cumulative incidence of SARS-CoV-2 infection among adults in three regions of France following the first lockdown and associated risk factors: a multicohort study
Beteiligte: Carrat, Fabrice; de Lamballerie, Xavier; Rahib, Delphine; Blanché, Hélène; Lapidus, Nathanael; Artaud, Fanny; Kab, Sofiane; Renuy, Adeline; Szabo de Edelenyi, Fabien; Meyer, Laurence; Lydié, Nathalie; Charles, Marie-Aline; Ancel, Pierre-Yves; Jusot, Florence; Rouquette, Alexandra; Priet, Stéphane; Saba Villarroel, Paola Mariela; Fourié, Toscane; Lusivika-Nzinga, Clovis; Nicol, Jérôme; Legot, Stephane; Druesne-Pecollo, Nathalie; Esseddik, Younes; Lai, Cindy; [...]
Erschienen: Oxford University Press (OUP), 2021
Erschienen in: International Journal of Epidemiology
Sprache: Englisch
DOI: 10.1093/ije/dyab110
ISSN: 1464-3685; 0300-5771
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Beschreibung: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>We aimed to estimate the seropositivity to anti-SARS-CoV-2 antibodies in May–June 2020 after the first lockdown period in adults living in three regions in France and to identify the associated risk factors.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Between 4 May 2020 and 23 June 2020, 16 000 participants in a survey on COVID-19 from an existing consortium of three general adult population cohorts living in the Ile-de-France (IDF) or Grand Est (GE) (two regions with high rate of COVID-19) or in the Nouvelle-Aquitaine (NA) (with a low rate) were randomly selected to take a dried-blood spot for anti-SARS-CoV-2 antibodies assessment with three different serological methods (ClinicalTrial Identifier #NCT04392388). The primary outcome was a positive anti-SARS-CoV-2 ELISA IgG result against the spike protein of the virus (ELISA-S). Estimates were adjusted using sampling weights and post-stratification methods. Multiple imputation was used to infer the cumulative incidence of SARS-CoV-2 infection with adjustments for imperfect tests accuracies.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>The analysis included 14 628 participants, 983 with a positive ELISA-S. The weighted estimates of seropositivity and cumulative incidence were 10.0% [95% confidence interval (CI): 9.1%, 10.9%] and 11.4% (95% CI: 10.1%, 12.8%) in IDF, 9.0% (95% CI: 7.7%, 10.2%) and 9.8% (95% CI: 8.1%, 11.8%) in GE and 3.1% (95% CI: 2.4%, 3.7%) and 2.9% (95% CI: 2.1%, 3.8%) in NA, respectively. Seropositivity was higher in younger participants [odds ratio (OR) = 1.84 (95% CI: 1.79, 6.09) in &lt;40 vs 50–60 years old and OR = 0.56 (95% CI: 0.42, 0.74) in ≥70 vs 50–60 years old)] and when at least one child or adolescent lived in the same household [OR = 1.30 (95% CI: 1.11, 1.53)] and was lower in smokers compared with non-smokers [OR = 0.71 (95% CI: 0.57, 0.89)].</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Seropositivity to anti-SARS-CoV-2 antibodies in the French adult population was ≤10% after the first wave. Modifiable and non-modifiable risk factors were identified.</jats:p> </jats:sec>
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