Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19

Medientyp: E-Artikel
Titel: Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19
Beteiligte: Kartsonaki, Christiana; Baillie, J Kenneth; Barrio, Noelia García; Baruch, Joaquín; Beane, Abigail; Blumberg, Lucille; Bozza, Fernando; Broadley, Tessa; Burrell, Aidan; Carson, Gail; Citarella, Barbara Wanjiru; Dagens, Andrew; Dankwa, Emmanuelle A; Donnelly, Christl A; Dunning, Jake; Elotmani, Loubna; Escher, Martina; Farshait, Nataly; Goffard, Jean-Christophe; Gonçalves, Bronner P; Hall, Matthew; Hashmi, Madiha; Sim Lim Heng, Benedict; Ho, Antonia; [...]
Erschienen: Oxford University Press (OUP), 2023
Erschienen in: International Journal of Epidemiology
Sprache: Englisch
DOI: 10.1093/ije/dyad012
ISSN: 0300-5771; 1464-3685
Schlagwörter: General Medicine ; Epidemiology
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Beschreibung: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID-19 cohort, one of the world's largest international, standardized data sets concerning hospitalized patients.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>The data set analysed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. We investigated how symptoms on admission, co-morbidities, risk factors and treatments varied by age, sex and other characteristics. We used Cox regression models to investigate associations between demographics, symptoms, co-morbidities and other factors with risk of death, admission to an intensive care unit (ICU) and invasive mechanical ventilation (IMV).</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Data were available for 689 572 patients with laboratory-confirmed (91.1%) or clinically diagnosed (8.9%) SARS-CoV-2 infection from 52 countries. Age [adjusted hazard ratio per 10 years 1.49 (95% CI 1.48, 1.49)] and male sex [1.23 (1.21, 1.24)] were associated with a higher risk of death. Rates of admission to an ICU and use of IMV increased with age up to age 60 years then dropped. Symptoms, co-morbidities and treatments varied by age and had varied associations with clinical outcomes. The case-fatality ratio varied by country partly due to differences in the clinical characteristics of recruited patients and was on average 21.5%.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Age was the strongest determinant of risk of death, with a ∼30-fold difference between the oldest and youngest groups; each of the co-morbidities included was associated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death. The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who have a higher risk of death.</jats:p> </jats:sec>

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