> Detailanzeige

Falcone, Marco; Suardi, Lorenzo Roberto; Tiseo, Giusy; Galfo, Valentina; Occhineri, Sara; Verdenelli, Stefano; Ceccarelli, Giancarlo; Poli, Melita; Merli, Marco; Bavaro, Davide; Carretta, Anna; Nunnari, Giuseppe; Venanzi Rullo, Emmanuele; Trecarichi, Enrico Maria; Papalini, Chiara; Franco, Antonina; Del Vecchio, Rosa Fontana; Bianco, Vincenzo; Punzi, Rodolfo; Francisci, Daniela; Rubino, Raffaella; Torti, Carlo; Puoti, Massimo; Carbonara, Sergio; [...]

Superinfections caused by carbapenem-resistant Enterobacterales in hospitalized patients with COVID-19: a multicentre observational study from Italy (CREVID Study)

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Superinfections caused by carbapenem-resistant Enterobacterales in hospitalized patients with COVID-19: a multicentre observational study from Italy (CREVID Study)
  • Beteiligte: Falcone, Marco; Suardi, Lorenzo Roberto; Tiseo, Giusy; Galfo, Valentina; Occhineri, Sara; Verdenelli, Stefano; Ceccarelli, Giancarlo; Poli, Melita; Merli, Marco; Bavaro, Davide; Carretta, Anna; Nunnari, Giuseppe; Venanzi Rullo, Emmanuele; Trecarichi, Enrico Maria; Papalini, Chiara; Franco, Antonina; Del Vecchio, Rosa Fontana; Bianco, Vincenzo; Punzi, Rodolfo; Francisci, Daniela; Rubino, Raffaella; Torti, Carlo; Puoti, Massimo; Carbonara, Sergio; [...]
  • Erschienen: Oxford University Press (OUP), 2022
  • Erschienen in: JAC-Antimicrobial Resistance
  • Sprache: Englisch
  • DOI: 10.1093/jacamr/dlac064
  • ISSN: 2632-1823
  • Schlagwörter: General Earth and Planetary Sciences ; General Environmental Science
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Objectives</jats:title> <jats:p>To describe clinical characteristics and outcomes of COVID-19 patients who developed secondary infections due to carbapenem-resistant Enterobacterales (CRE).</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Retrospective observational study including COVID-19 patients admitted to 12 Italian hospitals from March to December 2020 who developed a superinfection by CRE. Superinfection was defined as the occurrence of documented bacterial infection &amp;gt;48 h from admission. Patients with polymicrobial infections were excluded. Demographic, clinical characteristics and outcome were collected. Isolates were classified as KPC, metallo-β-lactamase (MBL) and OXA-48-producing CRE. A Cox regression analysis was performed to identify factors independently associated with 30 day mortality.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Overall, 123 patients (median age 66 years, IQR 59–75) were included. The majority of infections occurred in the ICU (81, 65.9%), while 42 (34.1%) in medical wards. The most common types of infection were bloodstream infections (BSI) (n = 64, 52%), followed by urinary-tract infections (UTI) (n = 28, 22.8%), hospital-acquired/ventilator-associated pneumonia (HAP/VAP) (n = 28, 22.8%), intra-abdominal infections (n = 2, 1.6%) and skin infections (n = 1, 0.8%). Sixty-three (51.2%) infections were caused by KPC-, 54 (43.9%) by MBL-, and 6 (4.8%) by OXA-48-producing CRE. Thirty-day mortality was 33.3% (41/123). On Cox regression analysis, HAP/VAP compared with UTI (HR 7.23, 95% CI 2.09–24.97, P = 0.004), BSI compared with UTI (HR 3.96, 95% CI, 1.33–11.77, P = 0.004), lymphopenia on admission (HR 3, 95% CI 1.44–6.26, P = 0.003) and age (HR 1.05, 95% CI 1.02–1.08, P = 0.002) were predictors of 30 day mortality.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Superinfections by CRE were associated with high risk of 30 day mortality in patients with COVID-19. HAP/VAP was the strongest predictor of death in these patients.</jats:p> </jats:sec>
  • Zugangsstatus: Freier Zugang