Clinical triage of patients on kidney replacement therapy presenting with COVID-19: an ERACODA registry analysis

Medientyp: E-Artikel
Titel: Clinical triage of patients on kidney replacement therapy presenting with COVID-19: an ERACODA registry analysis
Beteiligte: Mitra, Sandip; Jayanti, Anuradha; Vart, Priya; Coca, Armando; Gallieni, Maurizio; Øvrehus, Marius Altern; Midtvedt, Karsten; Abd ElHafeez, Samar; Gandolfini, Iliaria; Büttner, Stefan; Franssen, Casper F M; Hemmelder, Marc H; van der Net, Jeroen B; Essig, Marie; du Buf-Vereijken, Peggy W G; van Ginneken, Betty; Vogt, Nanda Maas Liffert; van Jaarsveld, Brigit C; Jager, Kitty J; Bemelman, Frederike J; Klingenberg-Salahova, Farah; Heenan-Vos, Frederiek; Vervloet, Marc G; Nurmohamed, Azam; [...]
Erschienen: Oxford University Press (OUP), 2021
Erschienen in: Nephrology Dialysis Transplantation
Sprache: Englisch
DOI: 10.1093/ndt/gfab196
ISSN: 0931-0509; 1460-2385
Schlagwörter: Transplantation ; Nephrology
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Beschreibung: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Patients on kidney replacement therapy (KRT) are at very high risk of coronavirus disease 2019 (COVID-19). The triage pathway for KRT patients presenting to hospitals with varying severity of COVID-19 illness remains ill-defined. We studied the clinical characteristics of patients at initial and subsequent hospital presentations and the impact on patient outcomes.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>The European Renal Association COVID-19 Database (ERACODA) was analysed for clinical and laboratory features of 1423 KRT patients with COVID-19 either hospitalized or non-hospitalized at initial triage and those re-presenting a second time. Predictors of outcomes (hospitalization, 28-day mortality) were then determined for all those not hospitalized at initial triage.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Among 1423 KRT patients with COVID-19 [haemodialysis (HD), n = 1017; transplant, n = 406), 25% (n = 355) were not hospitalized at first presentation due to mild illness (30% HD, 13% transplant). Of the non-hospitalized patients, only 10% (n = 36) re-presented a second time, with a 5-day median interval between the two presentations (interquartile range 2–7 days). Patients who re-presented had worsening respiratory symptoms, a decrease in oxygen saturation (97% versus 90%) and an increase in C-reactive protein (26 versus 73 mg/L) and were older (72 vs 63 years) compared with those who did not return a second time. The 28-day mortality between early admission (at first presentation) and deferred admission (at second presentation) was not significantly different (29% versus 25%; P = 0.6). Older age, prior smoking history, higher clinical frailty score and self-reported shortness of breath at first presentation were identified as risk predictors of mortality when re-presenting after discharge at initial triage.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>This study provides evidence that KRT patients with COVID-19 and mild illness can be managed effectively with supported outpatient care and with vigilance of respiratory symptoms, especially in those with risk factors for poor outcomes. Our findings support a risk-stratified clinical approach to admissions and discharges of KRT patients presenting with COVID-19 to aid clinical triage and optimize resource utilization during the ongoing pandemic.</jats:p> </jats:sec>
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