del Campo, Regina M Navarro-Martin;
Casillas-Toral, Erika;
Orozco-Alvarado, Ana L;
Sanchez-Zubieta, Fernando;
Arredondo-Navarro, Luis A;
Gutierrez-Oliva, Lorelai
LINC-09. TREATMENT AND OUTCOME IN CHILDREN WITH LOW-GRADE GLIOMAS IN WESTERN MEXICO: EXPERIENCE AT HOSPITAL CIVIL DE GUADALAJARA
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Medientyp:
E-Artikel
Titel:
LINC-09. TREATMENT AND OUTCOME IN CHILDREN WITH LOW-GRADE GLIOMAS IN WESTERN MEXICO: EXPERIENCE AT HOSPITAL CIVIL DE GUADALAJARA
Beteiligte:
del Campo, Regina M Navarro-Martin;
Casillas-Toral, Erika;
Orozco-Alvarado, Ana L;
Sanchez-Zubieta, Fernando;
Arredondo-Navarro, Luis A;
Gutierrez-Oliva, Lorelai
Beschreibung:
<jats:title>Abstract</jats:title>
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<jats:title>BACKGROUND</jats:title>
<jats:p>Brain tumors are the most common solid tumors in childhood, 35% of them being low-grade gliomas (LGGs). Few data is available regard LGGs in low-and-middle-income countries. This study evaluates LGGs in a tertiary center in Mexico. DESIGN: A retrospective review of clinical files of 105 children diagnosed with LGG other than optic nerve glioma from 2007 to 2019 was done.</jats:p>
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<jats:title>RESULTS</jats:title>
<jats:p>Median age at diagnosis was 7.2 years (from 5 months to 18 years). Male to female ratio was 0.75:1. WHO Grade I represented 68% of the cases. Anatomic sites were: posterior fossa (41%), supratentorial (43.5 %), spinal (8.5%), subependymal (6 %) and pineal (1%). Ten percent of patients had a diagnosed phacomatosis. Treatment was observation without surgery in 3.8%, surgery followed by observation in 49.5%, only chemotherapy in 2.8%, only radiotherapy in 6.7%, and surgery combined with chemotherapy or radiotherapy in 37.2% of cases. Among patients who had surgical intervention, 40% achieved gross total resection, 44% subtotal resection and 16% only biopsy. One or more recurrences were found in 20 % of patients. The 5 and 10-year overall survival (OS) was 83% and 73% respectively. The 5 and 10-year progression-free survival (PFS) was 66 % and 44 % respectively.</jats:p>
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<jats:title>CONCLUSIONS</jats:title>
<jats:p>In this series the OS were lower compared with countries with high income, reflecting the need to improve surgery, since only 40% achieved complete resection that is a determining factor for the prognosis. We observed a decrease in OS until 10-year follow and the PFS was even lower due to recurrence/progression.</jats:p>
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