832. Assessment of Risk Factors Associated with Wide-resistance Gram-negative Bacteria Infections

Medientyp: E-Artikel
Titel: 832. Assessment of Risk Factors Associated with Wide-resistance Gram-negative Bacteria Infections
Beteiligte: Reis, Henry Pablo Lopes Campos e; Rodrigues, Ana Beatriz Ferreira; Silva, Julio César Castro; de Lima, Lia Pinheiro; Quinaher, Talita Lima; de Freitas, Thaynara Carvalho; Pereira, Carla Mônica Porto; de Araujo, Breno Queiroz; Da Silva, Abel Brasil Ramos; Amaral, Germana Perdigão; de Souza, Geovania Maciel; Fragoso, Luciana Vladia Carvalhedo; Girão, Evelyne Santana; Pontes, Licia Borges; Junior, Arnaldo Aires Peixoto; Araujo, Vitor Nogueira; Duarte, Fernando Barroso; Barroso, Karine Sampaio Nunes; Rodrigues, Jorge Luiz Nobre
Erschienen: Oxford University Press (OUP), 2020
Erschienen in: Open Forum Infectious Diseases
Sprache: Englisch
DOI: 10.1093/ofid/ofaa439.1021
ISSN: 2328-8957
Schlagwörter: Infectious Diseases ; Oncology
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Beschreibung: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Enterobacteria and multidrug-resistant non-fermenting Gram-negative bacilli present a challenge in the management of invasive infections, leading to mortality rates due to their limited therapeutic arsenal. The objective of this work was to analyze risk factors that may be associated with these infections, for a better situational mapping and assertive decision-making in a university hospital in Brazil.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>The study was conducted between January and September 2019, with 167 patients in contact isolation at a university hospital in Brazil. Potential outcome-related variables for wide-resistance Gram-negative bacteria (BGN) infections were evaluated. Risk factors were identified from univariate statistical analysis using Fisher’s test.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>51 (30.5%) out of 167 patients in contact isolation evolved with wide-resistance BGN infection. Risk factors in univariate analysis were age, hospital unit and previous use of invasive devices. Patients aged up to 59 years were more likely to progress to infection than those aged over 60 years (p 0.0274, OR 2.2, 95% CI 1.1-4.5). Those admitted to the oncohematology (p &lt; 0.001, OR 32.5, Cl 9.1-116.3) and intensive care unit (p &lt; 0.001, OR 28.0, Cl 3.5-225.9) units were more likely to develop this type of infection. The least likely were those admitted to a kidney transplant unit (p 0.0034, OR 15.33, Cl 1.8-131.0). Prior use of mechanical ventilation (p 0.0058, OR 12.2, Cl 2.0-76.1) and delayed bladder catheter (p 0.0266, OR 5.0, Cl 1.2-20.1) in patients with respiratory and urinary tract infection, respectively, were also reported as risk factors related to these infections. The gender of the patients was not significant for the study.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>This study determined that variables such as age, hospitalization unit, use of mechanical ventilation and delayed bladder catheter could be considered important risk factors in triggering the infectious process by wide-resistant gram-negative bacteria. Thus, the analysis of these factors becomes a great foundation to prevent the development of multiresistant pathogens through prevention strategies, prophylaxis management and more targeted empirical therapies.</jats:p> </jats:sec> <jats:sec> <jats:title>Disclosures</jats:title> <jats:p>All Authors: No reported disclosures</jats:p> </jats:sec>
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