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De Baetselier, Irith; Vuylsteke, Bea; Cuylaerts, Vicky; Cuer, Benjamin; Yaya, Issifou; Mensah, Ephrem; Dah, Elias; Anoma, Camille; Koné, Amadou; Diandé, Souba; Dagnra, Anoumou; Fayé-Ketté, Hortense; Yeo, Alain; Smet, Hilde; Van den Bossche, Dorien; Keita, Bintou Dembélé; Spire, Bruno; Laurent, Christian; Crucitti, Tania; Laurent, Christian; Yaya, Issifou; Ouedraogo, Sayouba; Granouillac, Bruno; Cuer, Benjamin; [...]

Mycoplasma genitalium and Antimicrobial Resistance Among a Cohort of West African Men Who Have Sex With Men Using Preexposure Prophylaxis (CohMSM-PrEP ANRS 12369-Expertise France Study)

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  • Medientyp: E-Artikel
  • Titel: Mycoplasma genitalium and Antimicrobial Resistance Among a Cohort of West African Men Who Have Sex With Men Using Preexposure Prophylaxis (CohMSM-PrEP ANRS 12369-Expertise France Study)
  • Beteiligte: De Baetselier, Irith; Vuylsteke, Bea; Cuylaerts, Vicky; Cuer, Benjamin; Yaya, Issifou; Mensah, Ephrem; Dah, Elias; Anoma, Camille; Koné, Amadou; Diandé, Souba; Dagnra, Anoumou; Fayé-Ketté, Hortense; Yeo, Alain; Smet, Hilde; Van den Bossche, Dorien; Keita, Bintou Dembélé; Spire, Bruno; Laurent, Christian; Crucitti, Tania; Laurent, Christian; Yaya, Issifou; Ouedraogo, Sayouba; Granouillac, Bruno; Cuer, Benjamin; [...]
  • Erschienen: Oxford University Press (OUP), 2022
  • Erschienen in: Open Forum Infectious Diseases
  • Sprache: Englisch
  • DOI: 10.1093/ofid/ofac615
  • ISSN: 2328-8957
  • Schlagwörter: Infectious Diseases ; Oncology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Antimicrobial resistance to macrolides and fluoroquinolones in Mycoplasma genitalium (MG) among men who have sex with men (MSM) is worryingly high in high-resource countries. Data in Africa are lacking. We aimed to assess the burden of MG including the presence of resistance-associated mutations (RAMs) in MG among MSM using human immunodeficiency virus preexposure prophylaxis in Burkina Faso, Côte d’Ivoire, Mali, and Togo.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>MSM were included in a prospective cohort study (2017–2021). Molecular detection of MG in urine, anorectal, and pharyngeal samples was performed at baseline and after 6 and 12 months. Detection of RAMs to macrolides and fluoroquinolones was performed by sequencing the 23S ribosomal RNA, parC, and gyrA genes. A sample was found to be possibly resistant to fluoroquinolones if alterations were found in ParC position 83/87.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Of 598 participants, 173 (28.9%) were positive at least once for MG and global point-prevalence was 19.4%. Interestingly, 238 of 250 (95.2%) infections were asymptomatic and 72 of 138 MG infections with follow-up data (52.2%) cleared during the study. Only 1 macrolide RAM was found (0.6%). Prevalence of fluoroquinolones RAMs was 11.3% overall, ranging from 2.4% in Burkina Faso to 17.5% in Mali.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Although MG was highly prevalent in these MSM, macrolide resistance was almost nonexistent. Nevertheless, &amp;gt;10% of the samples were possibly resistant to fluoroquinolones. Heterogeneity in the prevalence of fluoroquinolone RAMs between countries may be explained by different antimicrobial consumption in humans and animals.</jats:p> </jats:sec>
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