Beschreibung:
<jats:title>Abstract</jats:title>
<jats:sec>
<jats:title>Background</jats:title>
<jats:p>Differentiating between functional bowel disorders and organic colonic disorders can often be difficult as they may be present with similar symptoms.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Aim of the Work</jats:title>
<jats:p>to evaluate the diagnostic value of plasma M2-pyruvate kinase level in differentiating functional colonic disorders (e.g: IBS) from organic colonic disorders (e.g: IBD, colorectal polyps and colorectal cancer) and to assess its use as screening tools for inflammatory bowel disease, premalignant and malignant colorectal lesions.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Patients and Methods</jats:title>
<jats:p>This study was conducted on 80 patients who divided into four groups:</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Group I</jats:title>
<jats:p>included 20 patients, representing functional bowel disorders (as a control group).</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Group II</jats:title>
<jats:p>included 20 patients with inflammatory bowel diseases;</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Group III</jats:title>
<jats:p>included 20 patients with colorectal polyps;</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Group IV</jats:title>
<jats:p>included 20 patients with colorectal cancer.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results</jats:title>
<jats:p>The current study showed that plasma M2 - PK can be used to differentiate functional from organic colonic lesions at a cut-off point &gt; 3 U/mL, with 93.33% sensitivity, 100% specificity, 100% PPV and 83.3% NPV. Also, plasma M2-PK can be used to discriminate between benign (colorectal polyp) and malignant colonic lesions (CRC) with a cut-off level of &gt; 12 U/ml, with 100% sensitivity, 100% specificity, 100% PPV and 100% NPV. Also, In the present study there was a highly significant + ve correlations between Plasma M2 PK level and CEA as (r = 0.787, p value = 0.000) and their combination can give higher sensitivity and specificity.</jats:p>
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<jats:sec>
<jats:title>Conclusion</jats:title>
<jats:p>Plasma M2-PK can differentiate between functional and organic colonic disorders as it is more elevated in organic than functional colonic disorders. Also, it is considered a promising rapid noninvasive biomarker for organic colonic disorders early detection and screening to reduce unnecessary endoscopic intervention.</jats:p>
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