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Mena-Vázquez, Natalia; Fernández-Nebro, Antonio; Pego-Reigosa, José María; Galindo, María; Melissa-Anzola, Ana; Uriarte-Isacelay, Esther; Olivé-Marqués, Alejandro; Aurrecoechea, Elena; Freire, Mercedes; Tomero, Eva; García-Villanueva, María Jesús; Stoye, Claudia; Salas-Heredia, Esteban; Bernal-Vidal, Jose Antonio; Salgado, Eva; Blanco, Ricardo; Javier Novoa, Francisco; Ibáñez-Barcelo, Mónica; Torrente-Segarra, Vicente; Narvaez, Javier; Calvet, Joan; Moriano Morales, Clara; Ramon Vazquez-Rodriguez, Tomas; Garcia de la Peña, Paloma; [...]

Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry

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  • Medientyp: E-Artikel
  • Titel: Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry
  • Beteiligte: Mena-Vázquez, Natalia; Fernández-Nebro, Antonio; Pego-Reigosa, José María; Galindo, María; Melissa-Anzola, Ana; Uriarte-Isacelay, Esther; Olivé-Marqués, Alejandro; Aurrecoechea, Elena; Freire, Mercedes; Tomero, Eva; García-Villanueva, María Jesús; Stoye, Claudia; Salas-Heredia, Esteban; Bernal-Vidal, Jose Antonio; Salgado, Eva; Blanco, Ricardo; Javier Novoa, Francisco; Ibáñez-Barcelo, Mónica; Torrente-Segarra, Vicente; Narvaez, Javier; Calvet, Joan; Moriano Morales, Clara; Ramon Vazquez-Rodriguez, Tomas; Garcia de la Peña, Paloma; [...]
  • Erschienen: Oxford University Press (OUP), 2020
  • Erschienen in: Rheumatology, 59 (2020) 8, Seite 2043-2051
  • Sprache: Englisch
  • DOI: 10.1093/rheumatology/kez562
  • ISSN: 1462-0324; 1462-0332
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Abstract Objectives This article estimates the frequency of polyautoimmunity and associated factors in a large retrospective cohort of patients with SLE. Methods RELESSER (Spanish Society of Rheumatology Lupus Registry) is a nationwide multicentre, hospital-based registry of SLE patients. This is a cross-sectional study. The main variable was polyautoimmunity, which was defined as the co-occurrence of SLE and another autoimmune disease, such as autoimmune thyroiditis, RA, scleroderma, inflammatory myopathy and MCTD. We also recorded the presence of multiple autoimmune syndrome, secondary SS, secondary APS and a family history of autoimmune disease. Multiple logistic regression analysis was performed to investigate possible risk factors for polyautoimmunity. Results Of the 3679 patients who fulfilled the criteria for SLE, 502 (13.6%) had polyautoimmunity. The most frequent types were autoimmune thyroiditis (7.9%), other systemic autoimmune diseases (6.2%), secondary SS (14.1%) and secondary APS (13.7%). Multiple autoimmune syndrome accounted for 10.2% of all cases of polyautoimmunity. A family history was recorded in 11.8%. According to the multivariate analysis, the factors associated with polyautoimmunity were female sex [odds ratio (95% CI), 1.72 (1.07, 2.72)], RP [1.63 (1.29, 2.05)], interstitial lung disease [3.35 (1.84, 6.01)], Jaccoud arthropathy [1.92 (1.40, 2.63)], anti-Ro/SSA and/or anti-La/SSB autoantibodies [2.03 (1.55, 2.67)], anti-RNP antibodies [1.48 (1.16, 1.90)], MTX [1.67 (1.26, 2.18)] and antimalarial drugs [0.50 (0.38, 0.67)]. Conclusion Patients with SLE frequently present polyautoimmunity. We observed clinical and analytical characteristics associated with polyautoimmunity. Our finding that antimalarial drugs protected against polyautoimmunity should be verified in future studies.
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